| Production of cortisol from cortisone by the isolated, perfused fetal rabbit lung. | |
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MedLine Citation:
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PMID: 941196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perfusion of the isolated 26 day fetal rabbit lung with 3H-cortisone resulted in its conversion to 3H-cortisol and release into the perfusate. Little conversion of 14C-cortisol to 14C-cortisone occurred. Quantitative study of homogenized fetal rabbit lung revealed the development of both the cofactor and the enzyme for 11beta-hydroxy steroid dehydrogenase activity between 21 and 29 days gestation. These results suggest increasing production of cortisol from cortisone by the fetal rabbit lung as a function of gestational age. This conversion may be of significance with respect to both lung development and parturition, both events being accelerated by cortisol treatment. |
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Authors:
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J S Torday; E B Olson; N L First |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Steroids Volume: 27 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 1976 Jun |
Date Detail:
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Created Date: 1976-09-25 Completed Date: 1976-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 869-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cortisone / metabolism* Gestational Age Hydrocortisone / biosynthesis* Hydroxysteroid Dehydrogenases / metabolism Lung / embryology, enzymology, metabolism* Perfusion Rabbits |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 53-06-5/Cortisone; EC 1.1.-/Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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