| Production of conditionally immortalised cell lines from a transgenic mouse. | |
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MedLine Citation:
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PMID: 9390819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review describes the H2kbtsA58 transgenic mouse (Immortomouse) and its application to the production of conditionally immortalised cell lines from sensory epithelia within the mammalian inner ear. Established cell lines should overcome many of the technical difficulties associated with experimental procedures in auditory and vestibular research. These include the limited amount of tissue available and the relatively complex and laborious dissection. Conditional immortalisation should also allow essential studies on the molecular and cellular mechanisms that govern both the differentiation of sensory cells and the development of sensory epithelia. |
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Authors:
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M C Holley; P W Lawlor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Audiology & neuro-otology Volume: 2 ISSN: 1420-3030 ISO Abbreviation: Audiol. Neurootol. Publication Date: 1997 Jan-Apr |
Date Detail:
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Created Date: 1998-01-06 Completed Date: 1998-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9606930 Medline TA: Audiol Neurootol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 25-35 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medical Sciences, University of Bristol, UK. m.c.holley@bristol.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Culture Techniques / methods Cell Differentiation Cell Line* Ear, Inner / cytology*, innervation Epithelial Cells / cytology Gene Expression Mice Mice, Transgenic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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