Document Detail

Production and circulation of cerebrospinal fluid with respect to the subarachnoid space of the optic nerve.
MedLine Citation:
PMID:  23733131     Owner:  NLM     Status:  In-Data-Review    
The function of cerebrospinal fluid (CSF) is to protect the brain and optic nerve from mechanical damage, provide nutrition for axons/neurons, and remove of toxic metabilites. CSF is produced mainly by the choroid plexus epithelium and ependymal cells of the ventricles and flows into interconnecting chambers; namely, the cisterns and the subarachnoid spaces. Based on studies of CSF circulation and direction of flow using radioisotopes and other tracers injected into the CSF, it is thought that there is a bulk circulation of fluid from the sites of production in the third, fourth, and lateral ventricles to the arachnoid villi and probably to the lymphatic capillaries in the cranial dura mater. The mechanism by which CSF is propelled is incompletely understood, but probably is influenced by the release of newly produced CSF, ventricular pulsations, and the pulse pressure of the vascular choroid plexus. This mechanism would account for the steady CSF pressure. In addition to the steady CSF pressure, overlapping pressure spikes occur during trunk inclination, coughing and other valsalva.
Hanspeter E Killer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  22 Suppl 5     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2013 Jun-Jul
Date Detail:
Created Date:  2013-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S8-S10     Citation Subset:  IM    
University of Basel, Head of Neuro-ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.
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