Document Detail

Production of chondroitin sulfate and chondroitin.
MedLine Citation:
PMID:  20521042     Owner:  NLM     Status:  MEDLINE    
The production of microbial polysaccharides has recently gained much interest because of their potential biotechnological applications. Several pathogenic bacteria are known to produce capsular polysaccharides, which provide a protection barrier towards harsh environmental conditions, and towards host defences in case of invasive infections. These capsules are often composed of glycosaminoglycan-like polymers. Glycosaminoglycans are essential structural components of the mammalian extracellular matrix and they have several applications in the medical, veterinary, pharmaceutical and cosmetic field because of their peculiar properties. Most of the commercially available glycosaminoglycans have so far been extracted from animal sources, and therefore the structural similarity of microbial capsular polysaccharides to these biomolecules makes these bacteria ideal candidates as non-animal sources of glycosaminoglycan-derived products. One example is hyaluronic acid which was formerly extracted from hen crests, but is nowadays produced via Streptococci fermentations. On the other hand, no large scale biotechnological production processes for heparin and chondrotin sulfate have been developed. The larger demand of these biopolymers compared to hyaluronic acid (tons vs kilograms), due to the higher titre in the final product (grams vs milligrams/dose), and the scarce scientific effort have hampered the successful development of fermentative processes. In this paper we present an overview of the diverse applications and production methods of chondroitin reported so far in literature with a specific focus on novel microbial biotechnological approaches.
Chiara Schiraldi; Donatella Cimini; Mario De Rosa
Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-03
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  87     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1209-20     Citation Subset:  IM    
Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Second University of Naples, via De Crecchio n degrees 7, 80138 Naples, Italy.
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MeSH Terms
Bacteria / chemistry,  genetics,  metabolism*
Bacterial Capsules / chemistry,  metabolism*,  therapeutic use
Chondroitin / chemistry,  metabolism*,  therapeutic use
Chondroitin Sulfates / chemistry,  metabolism,  therapeutic use
Drug Therapy
Industrial Microbiology*
Reg. No./Substance:
0/Bacterial Capsules; 9007-27-6/Chondroitin; 9007-28-7/Chondroitin Sulfates

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