Document Detail

Production of c9,t11- and t10,c12-conjugated linoleic acids in humans by Lactobacillus rhamnosus PL60.
MedLine Citation:
PMID:  20075628     Owner:  NLM     Status:  MEDLINE    
Lactobacillus rhamnosus PL60 was tested for whether it can produce c9,t11- and t10,c12-conjugated linoleic acids (CLAs) in human. After consumption of L. rhamnosus PL60, L. rhamnosus was detected in feces 1 week after the start of intake. Analysis by gas chromatography showed that concentrations of c9,t11- and t10,c12-CLAs in serum had increased and concentrations of serum leptin had significantly decreased. Results showed that L. rhamnosus PL60 can survive in human intestines and produce CLAs in human. This is the first report that bacteria can produce CLAs in humans.
Kieun Lee; Yeonhee Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microbiology and biotechnology     Volume:  19     ISSN:  1017-7825     ISO Abbreviation:  J. Microbiol. Biotechnol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431852     Medline TA:  J Microbiol Biotechnol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1617-9     Citation Subset:  IM    
Culture Collection of Antimicrobial Resistant Microbes, Department of Biology, Seoul Women's University, Seoul 139-744, Korea.
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MeSH Terms
Chromatography, Gas
DNA, Bacterial / genetics,  isolation & purification
Drug Administration Schedule
Feces / microbiology
Intestines / metabolism,  microbiology
Lactobacillus rhamnosus / genetics,  growth & development,  metabolism*
Leptin / blood
Linoleic Acids, Conjugated / biosynthesis*,  blood,  chemistry
Middle Aged
Obesity / metabolism,  prevention & control
Probiotics / administration & dosage
Time Factors
Reg. No./Substance:
0/DNA, Bacterial; 0/Leptin; 0/Linoleic Acids, Conjugated

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