| Production of brefeldin-A. | |
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MedLine Citation:
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PMID: 7662298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale. |
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Authors:
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T G McCloud; M P Burns; F D Majadly; G M Muschik; D A Miller; K K Poole; J M Roach; J T Ross; W B Lebherz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of industrial microbiology Volume: 15 ISSN: 0169-4146 ISO Abbreviation: J. Ind. Microbiol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2001-03-23 |
Medline Journal Info:
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Nlm Unique ID: 8610887 Medline TA: J Ind Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: B |
Affiliation:
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Chemical Synthesis and Analysis Laboratory, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
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isolation & purification,
metabolism* Brefeldin A Chromatography, High Pressure Liquid Cyclopentanes / isolation & purification, metabolism* Fermentation Industrial Microbiology Penicillium / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Cyclopentanes; 20350-15-6/Brefeldin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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