| Production of artemisinin by genetically-modified microbes. | |
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MedLine Citation:
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PMID: 18008167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Artemisinin, an endoperoxidized sesquiterpene originally extracted from the medicinal plant Artemisia annua L., is a potent malaria-killing agent. Due to the urgent demand and short supply of this new antimalarial drug, engineering enhanced production of artemisinin by genetically-modified or transgenic microbes is currently being explored. Cloning and expression of the artemisinin biosynthetic genes in Saccharomyces cerevisiae and Escherichia coli have led to large-scale microbial production of the artemisinin precursors such as amorpha-4,11-diene and artemisinic acid. Although reconstruction of the complete biosynthetic pathway toward artemisinin in transgenic yeast and bacteria has not been achieved, artemisinic acid available from these transgenic microbes facilitates the subsequent partial synthesis of artemisinin by either chemical or biotransformational process, thereby providing an attractive strategy alternative to the direct extraction of artemisinin from A.annua L. In this review, we update the current trends and summarize the future prospects on genetic engineering of the microorganisms capable of accumulating artemisinin precursors through heterologous and functional expression of the artemisinin biosynthetic genes. |
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Authors:
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Qingping Zeng; Frank Qiu; Ling Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-11-16 |
Journal Detail:
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Title: Biotechnology letters Volume: 30 ISSN: 0141-5492 ISO Abbreviation: Biotechnol. Lett. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-02-20 Completed Date: 2008-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008051 Medline TA: Biotechnol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 581-92 Citation Subset: IM |
Affiliation:
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Laboratory of Biotechnology, Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, China. qpzeng@gzhtcm.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Artemisinins
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chemistry,
metabolism* Escherichia coli / genetics, metabolism Genetic Engineering / methods* Molecular Structure Saccharomyces cerevisiae / genetics, metabolism Sesquiterpenes / chemistry, metabolism Technology, Pharmaceutical / methods* |
| Chemical | |
Reg. No./Substance:
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0/Artemisinins; 0/Sesquiterpenes; 0/amorpha-4,11-diene; 63968-64-9/artemisinine; 80286-58-4/artemisic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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