Document Detail


Production of adrenomedullin from synovial cells in rheumatoid arthritis patients.
MedLine Citation:
PMID:  12709825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It was recently reported that plasma levels of adrenomedullin (AM), identified as a vasorelaxant peptide, are significantly higher in rheumatoid arthritis (RA) patients than in osteoarthritis (OA) patients. The objective of the present study was to elucidate AM production in synovial cells from patients with RA. Adrenomedullin mRNA was detected in cultured synovial cells from RA patients by reverse transcription polymerase chain reaction (RT-PCR). Immunohistochemical analysis demonstrated the presence of AM in synovial cells from RA patients. In addition, we investigated AM levels in knee joint fluids from RA and OA patients. Those from RA patients were elevated approximately threefold over those of OA patients. In this study, we demonstrated for the first time AM expression in synovial cells from RA patients and high levels of AM production in RA joint fluid.
Authors:
T Matsushita; N Matsui; S Yoshiya; H Fujioka; M Kurosaka
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Publication Detail:
Type:  Journal Article     Date:  2003-04-23
Journal Detail:
Title:  Rheumatology international     Volume:  24     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku Kobe, Hyogo 650-0017, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Aged
Aged, 80 and over
Arthritis, Rheumatoid / genetics,  metabolism*,  pathology
Cells, Cultured
Humans
Knee Joint / metabolism,  pathology
Peptides / genetics,  metabolism,  secretion*
RNA, Messenger / metabolism
Synovial Membrane / metabolism,  pathology,  secretion*
Up-Regulation / genetics
Chemical
Reg. No./Substance:
0/Peptides; 0/RNA, Messenger; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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