| Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. | |
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MedLine Citation:
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PMID: 15888786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: A characteristic feature of Crohn's disease (CD) is mesenteric adipose tissue hypertrophy. Mesenteric adipocytes or specific proteins secreted by them may play a role in the pathogenesis of CD. We recently identified adiponectin as an adipocyte specific protein with anti-inflammatory properties. Here we report on expression of adiponectin in mesenteric adipose tissue of CD patients. METHODS AND RESULTS: Mesenteric adipose tissue specimens were obtained from patients with CD (n = 22), ulcerative colitis (UC) (n = 8) and, for controls, colon carcinoma patients (n = 28) who underwent intestinal resection. Adiponectin concentrations were determined by enzyme linked immunosorbent assay, and adiponectin mRNA levels were determined by real time quantitative reverse transcription-polymerase chain reaction. Tissue concentrations and release of adiponectin were significantly increased in hypertrophied mesenteric adipose tissue of CD patients compared with normal mesenteric adipose tissue of CD patients (p = 0.002, p = 0.040, respectively), UC patients (p = 0.002, p = 0.003), and controls (p<0.0001, p<0.0001). Adiponectin mRNA levels were significantly higher in hypertrophied mesenteric adipose tissue of CD patients than in paired normal mesenteric adipose tissue from the same subjects (p = 0.024). Adiponectin concentrations in hypertrophied mesenteric adipose tissue of CD patients with an internal fistula were significantly lower than those of CD patients without an internal fistula (p = 0.003). CONCLUSIONS: Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD. |
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Authors:
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K Yamamoto; T Kiyohara; Y Murayama; S Kihara; Y Okamoto; T Funahashi; T Ito; R Nezu; S Tsutsui; J-I Miyagawa; S Tamura; Y Matsuzawa; I Shimomura; Y Shinomura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 54 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-12 Completed Date: 2005-07-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 789-96 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamadaoka, Suita 565-0871, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism,
pathology Adiponectin Adipose Tissue / metabolism*, pathology Adult Body Mass Index Case-Control Studies Crohn Disease / metabolism*, pathology Female Humans Hypertrophy Intercellular Signaling Peptides and Proteins / metabolism* Interleukin-6 / metabolism Male Mesentery / metabolism*, pathology Middle Aged RNA, Messenger / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 0/RNA, Messenger |
| Comments/Corrections | |
Comment In:
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Gut. 2005 Jun;54(6):742-4
[PMID:
15888774
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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