Document Detail

Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.
MedLine Citation:
PMID:  15888786     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: A characteristic feature of Crohn's disease (CD) is mesenteric adipose tissue hypertrophy. Mesenteric adipocytes or specific proteins secreted by them may play a role in the pathogenesis of CD. We recently identified adiponectin as an adipocyte specific protein with anti-inflammatory properties. Here we report on expression of adiponectin in mesenteric adipose tissue of CD patients.
METHODS AND RESULTS: Mesenteric adipose tissue specimens were obtained from patients with CD (n = 22), ulcerative colitis (UC) (n = 8) and, for controls, colon carcinoma patients (n = 28) who underwent intestinal resection. Adiponectin concentrations were determined by enzyme linked immunosorbent assay, and adiponectin mRNA levels were determined by real time quantitative reverse transcription-polymerase chain reaction. Tissue concentrations and release of adiponectin were significantly increased in hypertrophied mesenteric adipose tissue of CD patients compared with normal mesenteric adipose tissue of CD patients (p = 0.002, p = 0.040, respectively), UC patients (p = 0.002, p = 0.003), and controls (p<0.0001, p<0.0001). Adiponectin mRNA levels were significantly higher in hypertrophied mesenteric adipose tissue of CD patients than in paired normal mesenteric adipose tissue from the same subjects (p = 0.024). Adiponectin concentrations in hypertrophied mesenteric adipose tissue of CD patients with an internal fistula were significantly lower than those of CD patients without an internal fistula (p = 0.003).
CONCLUSIONS: Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD.
K Yamamoto; T Kiyohara; Y Murayama; S Kihara; Y Okamoto; T Funahashi; T Ito; R Nezu; S Tsutsui; J-I Miyagawa; S Tamura; Y Matsuzawa; I Shimomura; Y Shinomura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  54     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-12     Completed Date:  2005-07-25     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-96     Citation Subset:  AIM; IM    
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamadaoka, Suita 565-0871, Japan.
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MeSH Terms
Adipocytes / metabolism,  pathology
Adipose Tissue / metabolism*,  pathology
Body Mass Index
Case-Control Studies
Crohn Disease / metabolism*,  pathology
Intercellular Signaling Peptides and Proteins / metabolism*
Interleukin-6 / metabolism
Mesentery / metabolism*,  pathology
Middle Aged
RNA, Messenger / metabolism
Reg. No./Substance:
0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 0/RNA, Messenger
Comment In:
Gut. 2005 Jun;54(6):742-4   [PMID:  15888774 ]

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