Document Detail


Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.
MedLine Citation:
PMID:  15888786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: A characteristic feature of Crohn's disease (CD) is mesenteric adipose tissue hypertrophy. Mesenteric adipocytes or specific proteins secreted by them may play a role in the pathogenesis of CD. We recently identified adiponectin as an adipocyte specific protein with anti-inflammatory properties. Here we report on expression of adiponectin in mesenteric adipose tissue of CD patients.
METHODS AND RESULTS: Mesenteric adipose tissue specimens were obtained from patients with CD (n = 22), ulcerative colitis (UC) (n = 8) and, for controls, colon carcinoma patients (n = 28) who underwent intestinal resection. Adiponectin concentrations were determined by enzyme linked immunosorbent assay, and adiponectin mRNA levels were determined by real time quantitative reverse transcription-polymerase chain reaction. Tissue concentrations and release of adiponectin were significantly increased in hypertrophied mesenteric adipose tissue of CD patients compared with normal mesenteric adipose tissue of CD patients (p = 0.002, p = 0.040, respectively), UC patients (p = 0.002, p = 0.003), and controls (p<0.0001, p<0.0001). Adiponectin mRNA levels were significantly higher in hypertrophied mesenteric adipose tissue of CD patients than in paired normal mesenteric adipose tissue from the same subjects (p = 0.024). Adiponectin concentrations in hypertrophied mesenteric adipose tissue of CD patients with an internal fistula were significantly lower than those of CD patients without an internal fistula (p = 0.003).
CONCLUSIONS: Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD.
Authors:
K Yamamoto; T Kiyohara; Y Murayama; S Kihara; Y Okamoto; T Funahashi; T Ito; R Nezu; S Tsutsui; J-I Miyagawa; S Tamura; Y Matsuzawa; I Shimomura; Y Shinomura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  54     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-12     Completed Date:  2005-07-25     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-96     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamadaoka, Suita 565-0871, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism,  pathology
Adiponectin
Adipose Tissue / metabolism*,  pathology
Adult
Body Mass Index
Case-Control Studies
Crohn Disease / metabolism*,  pathology
Female
Humans
Hypertrophy
Intercellular Signaling Peptides and Proteins / metabolism*
Interleukin-6 / metabolism
Male
Mesentery / metabolism*,  pathology
Middle Aged
RNA, Messenger / metabolism
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 0/RNA, Messenger
Comments/Corrections
Comment In:
Gut. 2005 Jun;54(6):742-4   [PMID:  15888774 ]

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