Document Detail


Production of PEG-modified bovine hemoglobin: economics and feasibility.
MedLine Citation:
PMID:  7994387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bovine hemoglobin has many advantages as a blood substitute: a) it's ready availability; b) it's low cost; c) it's oxygen carrying capacity; and d) the ease with which it can be modified with polyethylene glycol (PEG) to improve its pharmacokinetic profile. This study investigates the potential of PEG-modified bovine hemoglobin as a cost-effective blood substitute.
Authors:
R Bradley; S Sloshberg; K Nho; B Czuba; D Szesko; R Shorr
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  22     ISSN:  1073-1199     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  657-67     Citation Subset:  IM    
Affiliation:
Enzon, Inc., Piscataway, NJ 08854.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Substitutes / chemistry,  economics*,  isolation & purification*
Cattle
Chromatography, High Pressure Liquid
Cost-Benefit Analysis
Drug Contamination
Drug Stability
Endotoxins / analysis
Exchange Transfusion, Whole Blood
Hemoglobins / isolation & purification*,  metabolism
Hemoglobinuria / etiology
Humans
Methemoglobin / analysis
Oxygen / metabolism
Polyethylene Glycols*
Rats
Shock / metabolism,  therapy
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Endotoxins; 0/Hemoglobins; 0/Polyethylene Glycols; 7782-44-7/Oxygen; 9008-37-1/Methemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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