Document Detail


Production of an HLA-DRw13 antibody in a DRw14 positive multiparous woman.
MedLine Citation:
PMID:  3672492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A lymphocytotoxic HLA-DR alloantiserum (Ma159) which reacts with DR7, DR5 and DRw13 positive lymphocytes is described. It was non-cytotoxic against 27 DRw14 positive subjects and was not absorbed by DRw14 positive cells. The antiserum was produced by pregnancy alone in a DR4, DRw14 positive woman whose husband possesses DR7 and DRw13. Absorption and titration studies suggested that the antiserum contains separate antibodies directed towards DR7, DRw13 and a determinant shared by DR5 and DRw13. The implications of finding a specific anti-DRw13 antiserum and its production in a donor positive for the alternative subdivision of DRw6 are discussed.
Authors:
C Darke; J Street
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  30     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Blood Transfusion Centre, Cardiff, Wales, U.K.
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity
Female
HLA Antigens / analysis
HLA-D Antigens / immunology*
HLA-DR Antigens / classification,  immunology*
Humans
Isoantibodies / immunology*
Parity
Pedigree
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-D Antigens; 0/HLA-DR Antigens; 0/HLA-DR14; 0/HLA-DRw13; 0/Isoantibodies

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