Document Detail

The Production of Conjugated α-Linolenic, γ-Linolenic and Stearidonic Acids by Strains of Bifidobacteria and Propionibacteria.
MedLine Citation:
PMID:  22160449     Owner:  NLM     Status:  Publisher    
Conjugated fatty acids are regularly found in nature and have a history of biogenic activity in animals and humans. A number of these conjugated fatty acids are microbially produced and have been associated with potent anti-carcinogenic, anti-adipogenic, anti-atherosclerotic and anti-diabetogenic activities. Therefore, the identification of novel conjugated fatty acids is highly desirable. In this study, strains of bifidobacteria and propionibacteria previously shown by us and others to display linoleic acid isomerase activity were assessed for their ability to conjugate a range of other unsaturated fatty acids during fermentation. Only four, linoleic, α-linolenic, γ-linolenic and stearidonic acids, were converted to their respective conjugated isomers, conjugated linoleic acid (CLA), conjugated α-linolenic acid (CLNA), conjugated γ-linolenic acid (CGLA) and conjugated stearidonic acid (CSA), each of which contained a conjugated double bond at the 9,11 position. Of the strains assayed, Bifidobacterium breve DPC6330 proved the most effective conjugated fatty acid producer, bio-converting 70% of the linoleic acid to CLA, 90% of the α-linolenic acid to CLNA, 17% of the γ-linolenic acid to CGLA, and 28% of the stearidonic acid to CSA at a substrate concentration of 0.3 mg mL(-1). In conclusion, strains of bifidobacteria and propionibacteria can bio-convert linoleic, α-linolenic, γ-linolenic and stearidonic acids to their conjugated isomers via the activity of the enzyme linoleic acid isomerase. These conjugated fatty acids may offer the combined health promoting properties of conjugated fatty acids such as CLA and CLNA, along with those of the unsaturated fatty acids from which they are formed.
Alan A Hennessy; Eoin Barrett; R Paul Ross; Gerald F Fitzgerald; Rosaleen Devery; Catherine Stanton
Related Documents :
10393219 - Chylomicron metabolism in an animal model for hyperlipoproteinemia type i.
12196459 - Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal...
4249859 - The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adi...
11054609 - Metabolic abnormalities in cachexia and anorexia.
21816459 - Acids with an equivalent taste lead to different erosion of human dental enamel.
7033899 - Studies on elastic tissue of aorta in aortic dissections and marfan syndrome.
6768859 - Diurnal variation in oxidation of l-[1-(14)c]leucine and l-[1-(14)c]lysine in rats.
631319 - Antibacterial activity and chemical reactivity of sulphanylamides. rate constants of al...
21370819 - Trans fatty acid analyses in samples of marine origin: the risk of false positives.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-10
Journal Detail:
Title:  Lipids     Volume:  -     ISSN:  1558-9307     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Teagasc Food Research Centre, Moorepark, Fermoy, Co., Cork, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A self-contained, programmable microfluidic cell culture system with real-time microscopy access.
Next Document:  Paraoxonase 1 Activity in Chylomicrons and VLDL: The Effect of Type 2 Diabetes and Meals Rich in Sat...