| Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells. | |
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MedLine Citation:
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PMID: 12485870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, and cytochrome c (cyt c) was released to the cytosol. In addition, PG induced the cleavage of poly (ADP-ribose) polymerase (PARP). This study demonstrates that the activation of caspases-9, -8, and -3 mediates PG-induced apoptosis. |
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Authors:
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Beatriz Montaner; Ricardo Perez-Tomas |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 973 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-17 Completed Date: 2003-02-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 246-9 Citation Subset: IM |
Affiliation:
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Departament de Biologia Cellular i Anatomia Patològica Cancer Cell Biology Research Group, Universitat de Barcelona, Feixa Llarga s/n, E-08907 L'Hospitalet, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology Caspase 8 Caspase 9 Caspases / metabolism* Cytochrome c Group / metabolism* Cytosol / drug effects, metabolism Humans Jurkat Cells Kinetics Poly(ADP-ribose) Polymerases / metabolism Prodigiosin / pharmacology* Serratia marcescens |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cytochrome c Group; 82-89-3/Prodigiosin; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.4.22.-/CASP8 protein, human; EC 3.4.22.-/CASP9 protein, human; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
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