| Procyanidins from Apples (Malus pumila Mill.) Extend the Lifespan of Caenorhabditis elegans. | |
| | |
MedLine Citation:
|
PMID: 20717869 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Apple polyphenols (AP) mainly consist of procyanidins (PC), which are composed of (-)-epicatechins and (+)-catechins. In order to investigate the antiageing effects of PC, we measured the lifespan of CAENORHABDITIS ELEGANS worms treated with PC. Treatment with 65 µg/mL PC extended the mean lifespan of wild-type N2 and FEM-1 worms by 12.1 % and 8.4 %, respectively, i.e., to a similar extent as resveratrol. In addition, treatment with 100 µg/mL AP also significantly prolonged the mean lifespan of the same worms by 12.0 % and 5.3 %, respectively, i.e., to a similar extent as PC. In contrast, treatment with (-)-epicatechin did not extend the lifespan of the worms. PC did not modify the growth, food intake, or fecundity of C. ELEGANS. Treatment with PC did not extend the lifespan of MEV-1 worms, which show excessive oxidative stress, indicating that PC had no antioxidant ability in the MEV-1 mutant. Moreover, treatment with PC had no effect on the longevity of SIR-2.1 worms, which lack the activity of SIR-2, a member of the sirtuin family of NAD (+)-dependent protein deacetylases. These results indicated that PC has SIR-2.1-dependent antiageing effects on C. ELEGANS. |
| | |
Authors:
|
Tadahiro Sunagawa; Takahiko Shimizu; Tomomasa Kanda; Motoyuki Tagashira; Manabu Sami; Takuji Shirasawa |
Related Documents
:
|
17469769 - Stabilization of cranberry anthocyanins in nutraceutical capsules. 22984329 - The sanitary conditions of food service establishments and food safety knowledge and pr... 19008259 - Development and validation of an improved test for the measurement of human faecal elas... 16778469 - Inotropic and lusitropic effects of perilla frutescens (l.) britton extract on the rabb... 14509339 - Study of the polyphenol content of red and white grape varieties by liquid chromatograp... 16492529 - Anticariogenic activity of macelignan isolated from myristica fragrans (nutmeg) against... 15522349 - Resistance is useless?--extensions to the game theory of kleptoparasitism. 9172439 - The use of the bacteriocin, nisin, as a preservative in ricotta-type cheeses to control... 22473329 - Anti-obesity effects of the combined administration of cb1 receptor antagonist rimonaba... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-17 |
Journal Detail:
|
Title: Planta medica Volume: 77 ISSN: 1439-0221 ISO Abbreviation: Planta Med. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 122-7 Citation Subset: IM |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Research Laboratories for Fundamental Technology of Food, Asahi Breweries, Ltd., Ibaraki, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular targets of natural drug substances: idiosyncrasies and preferences.
Next Document: Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxi...