Document Detail

Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans.
MedLine Citation:
PMID:  20717869     Owner:  NLM     Status:  MEDLINE    
Apple polyphenols (AP) mainly consist of procyanidins (PC), which are composed of (-)-epicatechins and (+)-catechins. In order to investigate the antiageing effects of PC, we measured the lifespan of CAENORHABDITIS ELEGANS worms treated with PC. Treatment with 65 µg/mL PC extended the mean lifespan of wild-type N2 and FEM-1 worms by 12.1 % and 8.4 %, respectively, i.e., to a similar extent as resveratrol. In addition, treatment with 100 µg/mL AP also significantly prolonged the mean lifespan of the same worms by 12.0 % and 5.3 %, respectively, i.e., to a similar extent as PC. In contrast, treatment with (-)-epicatechin did not extend the lifespan of the worms. PC did not modify the growth, food intake, or fecundity of C. elegans. Treatment with PC did not extend the lifespan of MEV-1 worms, which show excessive oxidative stress, indicating that PC had no antioxidant ability in the MEV-1 mutant. Moreover, treatment with PC had no effect on the longevity of SIR-2.1 worms, which lack the activity of SIR-2, a member of the sirtuin family of NAD (+)-dependent protein deacetylases. These results indicated that PC has SIR-2.1-dependent antiageing effects on C. elegans.
Tadahiro Sunagawa; Takahiko Shimizu; Tomomasa Kanda; Motoyuki Tagashira; Manabu Sami; Takuji Shirasawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-17
Journal Detail:
Title:  Planta medica     Volume:  77     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-05-23     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  122-7     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Research Laboratories for Fundamental Technology of Food, Asahi Breweries, Ltd., Ibaraki, Japan.
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MeSH Terms
Caenorhabditis elegans / drug effects*,  genetics,  physiology*
Caenorhabditis elegans Proteins / genetics
Longevity / drug effects*
Malus / chemistry*
Proanthocyanidins / isolation & purification,  pharmacology*
Sirtuins / genetics
Stilbenes / pharmacology
Succinate Dehydrogenase / genetics
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Proanthocyanidins; 0/Stilbenes; EC protein, C elegans; EC Dehydrogenase; EC 3.5.1.-/SIR-2.1 protein, C elegans; EC 3.5.1.-/Sirtuins; Q369O8926L/resveratrol

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