Document Detail

Procyanidins improve some disrupted glucose homoeostatic situations: an analysis of doses and treatments according to different animal models.
MedLine Citation:
PMID:  22530710     Owner:  NLM     Status:  MEDLINE    
This review analyses the potential beneficial effects of procyanidins, the main class of flavonoids, in situations in which glucose homeostasis is disrupted. Because the disruption of glucose homeostasis can occur as a result of various causes, we critically review the effects of procyanidins based on the specific origin of each type of disruption. Where little or no insulin is present (Type I diabetic animals), summarized studies of procyanidin treatment suggest that procyanidins have a short-lived insulin-mimetic effect on the internal targets of the organism, an effect not reproduced in normoglycemic, normoinsulinemic healthy animals. Insulin resistance (usually linked to hyperinsulinemia) poses a very different situation. Preventive studies using fructose-fed models indicate that procyanidins may be useful in preventing the induction of damage and thus in limiting hyperglycemia. But the results of other studies using models such as high-fat diet treated rats or genetically obese animals are controversial. Although the effects on glucose parameters are hazy, it is known that procyanidins target key tissues involved in its homeostasis. Interestingly, all available data suggest that procyanidins are more effective when administered in one acute load than when mixed with food.
Montserrat Pinent; Lidia Cedó; Gemma Montagut; Mayte Blay; Anna Ardévol
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in food science and nutrition     Volume:  52     ISSN:  1549-7852     ISO Abbreviation:  Crit Rev Food Sci Nutr     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-25     Completed Date:  2012-08-07     Revised Date:  2012-09-21    
Medline Journal Info:
Nlm Unique ID:  8914818     Medline TA:  Crit Rev Food Sci Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  569-84     Citation Subset:  IM    
Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili (URV), Tarragona, Spain.
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MeSH Terms
Blood Glucose / analysis
Dietary Supplements
Disease Models, Animal
Glucose / metabolism
Glucose Metabolism Disorders / blood,  diet therapy,  drug therapy*,  metabolism
Hypoglycemic Agents / administration & dosage,  therapeutic use*
Insulin Resistance
Plant Extracts / chemistry,  therapeutic use
Proanthocyanidins / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/Proanthocyanidins; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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