Document Detail


Procyanidins From Japanese Quince (Chaenomeles Japonica) Fruit Induce Apoptosis in Human Colon Cancer Caco-2 Cells in a Degree of Polymerization-Dependent Manner.
MedLine Citation:
PMID:  22026386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Plant proanthocyanidins, including procyanidins, display various biological activities. Here we report an inhibition of human colon cancer Caco-2 cell growth by the extract from Japanese quince fruit and the procyanidin-rich fractions of the extract. We observed that the amount of apoptotic Caco-2 cells increased by 52.1% vs. control after 72-h incubation with 50 μg extract/mL, as assessed by flow cytometry and image cytometry. Under the same experimental conditions the corresponding values for human colon cancer HT-29 cells and for rat normal intestinal IEC-6 cells were 5.0% and 8.1%, respectively. The extract fractions enriched with higher oligomers exhibited the highest proapoptotic activity. In conclusion, the Japanese quince procyanidins exhibited proapoptotic activity in Caco-2 cells within a submilimolar concentration range.
Authors:
Sylwia Gorlach; Waldemar Wagner; Anna Podsędek; Karolina Szewczyk; Maria Koziołkiewicz; Jarosław Dastych
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-25
Journal Detail:
Title:  Nutrition and cancer     Volume:  -     ISSN:  1532-7914     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Institute of Technical Biochemistry , Technical University of Lodz , Lodz , Poland.
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