| Proconvulsive effects of the mitochondrial respiratory chain inhibitor--3-nitropropionic acid. | |
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MedLine Citation:
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PMID: 10973624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of impaired mitochondrial function in processes leading to the generation of seizures was studied in mice. An inhibitor of mitochondrial complex III, 3-nitropropionic acid, which is known to evoke convulsions per se, and was used here in subthreshold dose, enhanced seizures generated by electric current and application of 4-aminopyridine. In contrast, 3-nitropropionic acid did not affect convulsions induced by gamma-aminobutyric acid (GABA) receptor antagonists - bicuculline, pentylenetetrazol and picrotoxin, glycine antagonist - strychnine, cholinomimetic drug-pilocarpine, and kynurenine aminotransferase inhibitor - aminooxyacetic acid. It is hypothesised that deranged mitochondrial metabolism renders the central nervous system more susceptible to factors inducing seizures via direct depolarization. |
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Authors:
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G Haberek; T Tomczyk; B Zuchora; M Wielosz; W A Turski; E M Urbanska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 403 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-07 Completed Date: 2000-11-07 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 229-33 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, 20-090, Lublin, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Convulsants / pharmacology* Drug Interactions Electric Stimulation Electron Transport / drug effects* Electroshock Excitatory Amino Acid Antagonists / metabolism Glycine / pharmacology Kynurenic Acid / metabolism Male Mice Nitro Compounds Potassium Channels / drug effects, metabolism Propionic Acids / pharmacology* Seizures / chemically induced Synaptic Transmission / drug effects gamma-Aminobutyric Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Convulsants; 0/Excitatory Amino Acid Antagonists; 0/Nitro Compounds; 0/Potassium Channels; 0/Propionic Acids; 492-27-3/Kynurenic Acid; 504-88-1/3-nitropropionic acid; 51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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