Document Detail


Procoagulants and anticoagulants in fetal blood. A literature survey.
MedLine Citation:
PMID:  20430718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In intrauterine life, hemostasis is maintained by the same components as in extrauterine life (blood platelets, coagulation and fibrinolysis systems, involvement of the vascular wall); in the fetus, however, these components show significant differences of a quantitative/qualitative nature. In the present study, we surveyed the literature on the coagulation system in the fetus. We focused on the velocity of development of the coagulation system, being reflected in the increased concentration of all procoagulants and anticoagulants (a rise from approximately 20% in the middle of pregnancy to about 60% or more in the period of labor; exceptions: factors V, VIII and XIII which in the labor period reach the adult level) and screening test results (prothrombin time, aPTT - activated prothrombin time, and thrombin time). Reference values were given for the 19-38 weeks of pregnancy and the labor term. Biochemical features of fetal fibrinogen and PIVKA factors were also discussed. The role of activated protein C (APC) in the maintenance of balance between procoagulants and anticoagulants was postulated as well as the role of APC in the formation of thrombin activatable fibrinolysis inhibitor (TAFI).
Authors:
Mieczysław Uszyński; Waldemar Uszyński; Marek Szymański
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  47     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Affiliation:
Department of Propedeutics of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland. kizproped@cm.umk.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / blood*
Blood Coagulation Factors / metabolism*
Female
Fetal Blood / metabolism*
Gestational Age
Hemostasis / physiology
Humans
Pregnancy
Protein C / metabolism
Thrombin / metabolism
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Blood Coagulation Factors; 0/Protein C; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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