| Procoagulant state in heart failure with preserved left ventricular ejection fraction. | |
| | |
MedLine Citation:
|
PMID: 19809208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The impact of heart failure with preserved left ventricular ejection fraction (LVEF) on activated hemostasis is still unclear. We sought to compare the activation of hemostasis in patients with heart failure with preserved LVEF, with impaired LVEF, and in healthy controls. Biomarkers of coagulation and fibrinolysis (D-dimer, tPA and PAI-1) were determined in outpatients with chronic stable (NYHA I-III), optimally managed heart failure with preserved LVEF (n = 46) and with impaired LVEF (n = 52), and in healthy age- and gender-matched controls (n = 14). In comparison to healthy controls, patients with heart failure and preserved LVEF had increased median D-dimer levels (606 [330-1222] microg/L versus 174 [86-249] microg/L; P < 0.001), and median PAI-1 (20 [15.3-33.1] microg versus 6.2[3.4-8.9] microg/L; P < 0.001) and tPA antigen concentrations (9.6 [8.1-13.3] versus 3.6 [2.2-5.0] microg/L; P < 0.001). However, unlike tPA and PAI antigens, D-dimer levels in preserved LVEF did not reach values as high as in impaired LVEF (917 [454-1185] microg/L; P = 0.013). Moreover, in patients with impaired LVEF, but not in those with preserved LVEF, age and NT-proBNP emerged as independent predictors of log-transformed D-dimer levels. Heart failure with preserved LVEF is associated with a procoagulant state as determined by increased levels of D-dimer, tPA and PAI-1 antigens. D-dimer levels are significantly higher in patients with impaired LVEF, while tPA and PAI-1 levels are increased regardless of LVEF. |
| | |
Authors:
|
Borut Jug; Nina Vene; Barbara Guzic Salobir; Miran Sebestjen; Miso Sabovic; Irena Keber |
Related Documents
:
|
17545818 - Preparing for the worst while hoping for the best: the relevance of hope in the heart f... 9347288 - Prediction of resting energy needs in older men with heart failure. 17760848 - Zonula occludens-1 and connexin 43 expression in the failing human heart. 17719768 - 111indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 ex... 3712448 - Sympathetic neural mechanisms in cardiac arrhythmias. 17761458 - Incremental prognostic value of restrictive filling pattern in hypertrophic cardiomyopa... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International heart journal Volume: 50 ISSN: 1349-2365 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-10-07 Completed Date: 2009-11-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: Japan |
Other Details:
|
Languages: eng Pagination: 591-600 Citation Subset: IM |
Affiliation:
|
Department of Vascular Diseases, Clinic of Internal Medicine, University Clinical Center Ljubljana, Ljubljana, Slovenia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Fibrin Fibrinogen Degradation Products / analysis Heart Failure / physiopathology* Hemostasis Humans Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood Peptide Fragments / blood Plasminogen Inactivators / blood Stroke Volume Tissue Plasminogen Activator / blood Ventricular Dysfunction, Left / physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Plasminogen Inactivators; 0/fibrin fragment D; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The influences of red blood cell transfusion on perioperative inflammatory responses using a miniatu...
Next Document: Is allogeneic blood transfusion a risk factor for sternal dehiscence following cardiac surgery? A pr...