Document Detail

Procoagulant effects of intraocular sodium hyaluronate (Healon) after phakic diabetic vitrectomy. A prospective, randomized study.
MedLine Citation:
PMID:  2685709     Owner:  NLM     Status:  MEDLINE    
A procoagulant effect was reported previously after injection of 0.50 to 0.75 ml of sodium hyaluronate (Healon) into the vitreous cavity at the end of phakic diabetic vitrectomies. A multicenter, randomized, prospective trial was done to study this effect. In the treatment group the media was clear in 50% of eyes in the immediate postoperative period compared with only 8% in the control group. At 2 to 6 weeks, there was no statistically significant difference between the two groups. The authors conclude that such sodium hyaluronate injection provides clear media in a significant number of eyes in the immediate postoperative period, potentially allowing thorough postoperative evaluation and early retinal photocoagulation if needed.
A J Packer; B W McCuen; W L Hutton; R C Ramsay
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Ophthalmology     Volume:  96     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-11     Completed Date:  1990-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1491-4     Citation Subset:  IM    
Department of Ophthalmology, Louisiana State University, New Orleans.
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MeSH Terms
Coagulants / adverse effects,  therapeutic use*
Diabetic Retinopathy / surgery*
Hyaluronic Acid / adverse effects,  pharmacology*
Intraocular Pressure / drug effects
Middle Aged
Multicenter Studies as Topic
Postoperative Care
Prospective Studies
Random Allocation
Vitrectomy* / adverse effects
Vitreous Hemorrhage / drug therapy,  etiology
Reg. No./Substance:
0/Coagulants; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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