Document Detail


Processive ubiquitin chain formation by the anaphase-promoting complex.
MedLine Citation:
PMID:  21477659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis.
Authors:
Hermann-Josef Meyer; Michael Rape
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-06
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  22     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-19     Completed Date:  2012-02-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  544-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anaphase-Promoting Complex-Cyclosome
Animals
Cell Nucleus / genetics,  metabolism*
Gene Expression Regulation, Developmental
Humans
Mammals
Mitosis*
Proteasome Endopeptidase Complex / genetics,  metabolism*
Protein Binding / genetics
Proteolysis
Substrate Specificity
Ubiquitin / genetics,  metabolism*
Ubiquitin-Conjugating Enzymes / genetics,  metabolism*
Ubiquitin-Protein Ligase Complexes / genetics,  metabolism*
Ubiquitination
Grant Support
ID/Acronym/Agency:
1DP2OD003088/OD/NIH HHS; 5R01GM083064-03/GM/NIGMS NIH HHS; DP2 OD003088/OD/NIH HHS; DP2 OD003088-01/OD/NIH HHS; R01 GM083064/GM/NIGMS NIH HHS; R01 GM083064-04/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Ubiquitin; EC 3.4.25.1/Proteasome Endopeptidase Complex; EC 6.3.2.19/Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19/Ubiquitin-Conjugating Enzymes; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes
Comments/Corrections

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