| Processive ubiquitin chain formation by the anaphase-promoting complex. | |
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MedLine Citation:
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PMID: 21477659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis. |
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Authors:
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Hermann-Josef Meyer; Michael Rape |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-04-06 |
Journal Detail:
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Title: Seminars in cell & developmental biology Volume: 22 ISSN: 1096-3634 ISO Abbreviation: Semin. Cell Dev. Biol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-10-19 Completed Date: 2012-02-09 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 9607332 Medline TA: Semin Cell Dev Biol Country: England |
Other Details:
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Languages: eng Pagination: 544-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of California at Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720-3202, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / genetics, metabolism* Gene Expression Regulation, Developmental Humans Mammals Mitosis* Proteasome Endopeptidase Complex / genetics, metabolism* Protein Binding / genetics Proteolysis Substrate Specificity Ubiquitin / genetics, metabolism* Ubiquitin-Conjugating Enzymes / genetics, metabolism* Ubiquitin-Protein Ligase Complexes / genetics, metabolism* Ubiquitination |
| Grant Support | |
ID/Acronym/Agency:
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1DP2OD003088/OD/NIH HHS; 5R01GM083064-03/GM/NIGMS NIH HHS; DP2 OD003088-01/OD/NIH HHS; R01 GM083064-04/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ubiquitin; EC 3.4.25.1/Proteasome Endopeptidase Complex; EC 6.3.2.19/Ubiquitin-Conjugating Enzymes; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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