Document Detail


Processing of vestibular inputs by the medullary lateral tegmental field of conscious cats: implications for generation of motion sickness.
MedLine Citation:
PMID:  23274644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dorsolateral reticular formation of the caudal medulla, the lateral tegmental field (LTF), participates in generating vomiting. LTF neurons exhibited complex responses to vestibular stimulation in decerebrate cats, indicating that they received converging inputs from a variety of labyrinthine receptors. Such a convergence pattern of vestibular inputs is appropriate for a brain region that participates in generating motion sickness. Since responses of brainstem neurons to vestibular stimulation can differ between decerebrate and conscious animals, the current study examined the effects of whole-body rotations in vertical planes on the activity of LTF neurons in conscious felines. Wobble stimuli, fixed-amplitude tilts, the direction of which moves around the animal at a constant speed, were used to determine the response vector orientation, and also to ascertain whether neurons had spatial-temporal convergence (STC) behavior (which is due to the convergence of vestibular inputs with different spatial and temporal properties). The proportion of LTF neurons with STC behavior in conscious animals (25 %) was similar to that in decerebrate cats. Far fewer neurons in other regions of the feline brainstem had STC behavior, confirming findings that many LTF neurons receive converging inputs from a variety of labyrinthine receptors. However, responses to vertical plane vestibular stimulation were considerably different in decerebrate and conscious felines for LTF neurons lacking STC behavior. In decerebrate cats, most LTF neurons had graviceptive responses to rotations, similar to those of otolith organ afferents. However, in conscious animals, the response properties were similar to those of semicircular canal afferents. These differences show that higher centers of the brain that are removed during decerebration regulate the labyrinthine inputs relayed to the LTF, either by gating connections in the brainstem or by conveying vestibular inputs directly to the region.
Authors:
Andrew A McCall; Jennifer D Moy; William M DeMayo; Sonya R Puterbaugh; Daniel J Miller; Michael F Catanzaro; Bill J Yates
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-29
Journal Detail:
Title:  Experimental brain research     Volume:  225     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  349-59     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Brain Mapping
Cats
Consciousness*
Decerebrate State
Medulla Oblongata / cytology*,  injuries
Neurons / physiology*
Vestibule, Labyrinth / injuries,  physiology*
Grant Support
ID/Acronym/Agency:
R01 DC003732/DC/NIDCD NIH HHS; R01-DC003732/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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