| Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: reproducibility of structural measures and micro-finite element analysis derived mechanical properties. | |
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MedLine Citation:
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PMID: 12030542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors have developed a system for the characterization of trabecular bone structure from high-resolution MR images. It features largely automated coil inhomogeneity correction, trabecular bone region segmentation, serial image registration, bone/marrow binarization, and structural calculation steps. The system addresses problems of efficiency and inter- and intraoperator variability inherent in previous analyses. The system is evaluated on repetitive scans of 8 volunteers for both two-dimensional (2D) apparent structure calculations and three-dimensional (3D) mechanical calculations using micro-finite element analysis. Coil correction methods based on a priori knowledge of the coil sensitivity and on low-pass filtering of the high-resolution mages are compared and found to perform similarly. Image alignment is found to cause small but significant changes in some structural parameters. Overall the automated system provides on the order of a 3-fold decrease in trained operator time over previous manual methods. Reproducibility is found to be dependent on image quality for most parameters. For 7 subjects with good image quality, reproducibility of 2-4% is found for 2D structural parameters, while 3D mechanical parameters vary by 4-9%, with percent standardized coefficients of variation in the ranges of 15-34% and 20-38% respectively. |
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Authors:
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D C Newitt; B van Rietbergen; S Majumdar |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 13 ISSN: 0937-941X ISO Abbreviation: Osteoporos Int Publication Date: 2002 |
Date Detail:
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Created Date: 2002-05-27 Completed Date: 2002-06-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
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Languages: eng Pagination: 278-87 Citation Subset: IM |
Affiliation:
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MRSC, Department of Radiology, University of California, San Francisco 94143-1290, USA. newitt@mrsc.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biomechanics Bone Density* Bone and Bones / physiopathology* Female Finite Element Analysis Humans Longitudinal Studies Magnetic Resonance Imaging / methods* Male Middle Aged Osteoporosis / diagnosis* Reproducibility of Results |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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