Document Detail


Process simulation in the pharmaceutical industry: a review of some basic physical models.
MedLine Citation:
PMID:  16447175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study reviews process modeling efforts which have been developed to elucidate the fundamental physical process underlying the manufacture and delivery of pharmaceutical dosage forms. Within the pharmaceutical industry, process models have been applied to a diverse array of physical processes at length and time scales that vary by orders of magnitude. As such, both large-scale continuum and particle-scale discrete approaches will be discussed in this study. Challenges associated with the practical application of process models within the pharmaceutical industry will be discussed, and opportunities for future research will be identified.
Authors:
D M Kremer; B C Hancock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  95     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-05-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-29     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
Affiliation:
Pharmaceutical Research and Development, Pfizer, Inc., Global Research and Development, Groton/New London Laboratories, Connecticut 06340, USA. douglas.m.kremer@pfizer.com
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical*
Drug Industry
Models, Theoretical*
Physical Phenomena
Physics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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