Document Detail

Process-scale disruption of microorganisms.
MedLine Citation:
PMID:  14536098     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Common hosts for the large-scale manufacture of biological products, such as Escherichia coli and Saccharomyces cerevisiae, do not excrete products to the medium. Effective techniques for cell disruption are therefore required. These include physical, chemical, enzymatic and mechanical methods. Mechanical methods such as bead milling, high-pressure homogenization, and microfluidization are preferred. However, gentler, specific methods are receiving increasing attention particularly when used in combination to synergistically exploit their different specificities. Benefits can also be derived by integrating product release and recovery. In all cases it is essential to consider the interaction of the disruption operation with downstream units and to clearly demonstrate the cost benefits of alternative strategies.
A P Middelberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biotechnology advances     Volume:  13     ISSN:  0734-9750     ISO Abbreviation:  Biotechnol. Adv.     Publication Date:  1995  
Date Detail:
Created Date:  2003-10-10     Completed Date:  2003-12-23     Revised Date:  2006-07-07    
Medline Journal Info:
Nlm Unique ID:  8403708     Medline TA:  Biotechnol Adv     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-551     Citation Subset:  -    
Co-operative Research Centre for Tissue Growth and Repair, Department of Chemical Engineering, The University of Adelaide, SA 5005, Australia.
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