Document Detail


Process of measuring in clinical medicine--implications of different definitions in clinical therapeutic studies.
MedLine Citation:
PMID:  17489029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Often, the decision whether a patient can be considered as healthy or ill is very difficult and depends on measurements and the interpretation of the results. Therefore, it is necessary to build and establish devices that base on certain pre-considerations (who should assess the data, when and how should be measured). Additionally, these devices have to be valid, reliable and responsive. According to the literature we came to the conclusion that no uniform definition of what is 'healthy' exists. Referring to mathematical considerations we show an approach to solve this problem especially when the device is a scale. Based on the quality of the scale and of certain pre-considerations, normal ranges can be established that will help to distinguish whether patients are 'healthy' or 'ill'. In this short review we discuss the problem of the establishment of a cut-off level on the basis of devices and we try to point out a solution to solve the arising problems.
Authors:
Andree Beckerling; Waldemar Braun; Michael Sommer
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-05-04
Journal Detail:
Title:  Digestion     Volume:  75 Suppl 1     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-09     Completed Date:  2007-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Affiliation:
IFE Institute for Research and Development at the University Witten/Herdecke, Witten, Germany. office@ife-europe.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Ulcer Agents / administration & dosage*
Clinical Medicine / standards*,  trends
Dose-Response Relationship, Drug
Evidence-Based Medicine
Female
Gastroesophageal Reflux / diagnosis,  drug therapy*
Humans
Male
Omeprazole / administration & dosage*
Prognosis
Randomized Controlled Trials as Topic
Reference Values
Reproducibility of Results
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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