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The Process of Kinetochore Assembly in Yeasts.
MedLine Citation:
PMID:  23039831     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
High fidelity chromosome segregation is essential for efficient transfer of the genetic material from the mother to daughter cells. The kinetochore, which connects the centromere DNA to the spindle apparatus, plays a pivotal role in this process. In spite of considerable divergence in the centromere DNA sequence, basic architecture of a kinetochore is evolutionarily conserved from yeast to humans. However, the identification of a large number of kinetochore proteins paved the way of understanding conserved and diverged regulatory steps that lead to formation of a multi-protein kinetochore super-complex on the centromere DNA in different organisms. Since it is a daunting task to summarize the entire spectrum of information in a mini-review, we focus here on the recent understanding in the process of kinetochore assembly in three yeasts: Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida albicans. Studies in these unicellular organisms suggest that although the basic process of kinetochore assembly remains the same, the dependence of a conserved protein for its kinetochore localization may vary in these organisms. © 2012 Federation of European Microbiological Societies. Published by Blackwell PublishingLtd. All rights reserved.
Authors:
Babhrubahan Roy; Neha Varshney; Vikas Yadav; Kaustuv Sanyal
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  FEMS microbiology letters     Volume:  -     ISSN:  1574-6968     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Post, Bangalore, 560 064, India.
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