| Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. | |
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MedLine Citation:
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PMID: 20014119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The RASopathies are a group of genetic syndromes caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Some of these syndromes are neurofibromatosis type 1, Noonan syndrome, Costello syndrome, cardio-facio-cutaneous syndrome, LEOPARD syndrome and Legius syndrome. Their common underlying pathogenetic mechanism brings about significant overlap in phenotypic features and includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium "Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back" chronicle the timely and typical research symposium which brought together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras syndromes and their families. The goals, to discuss basic science and clinical issues, to set forth a solid framework for future research, to direct translational applications towards therapy and to set forth best practices for individuals with RASopathies were successfully meet with a commitment to begin to move towards clinical trials. |
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Authors:
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Katherine A Rauen; Lisa Schoyer; Frank McCormick; Angela E Lin; Judith E Allanson; David A Stevenson; Karen W Gripp; Giovanni Neri; John C Carey; Eric Legius; Marco Tartaglia; Suzanne Schubbert; Amy E Roberts; Bruce D Gelb; Kevin Shannon; David H Gutmann; Martin McMahon; Carmen Guerra; James A Fagin; Benjamin Yu; Yoko Aoki; Benjamin G Neel; Allan Balmain; Richard R Drake; Garry P Nolan; Martin Zenker; Gideon Bollag; Judith Sebolt-Leopold; Jackson B Gibbs; Alcino J Silva; E Elizabeth Patton; David H Viskochil; Mark W Kieran; Bruce R Korf; Randi J Hagerman; Roger J Packer; Teri Melese |
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Publication Detail:
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Type: Congresses; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: 152A ISSN: 1552-4833 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-29 Completed Date: 2010-04-05 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
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Languages: eng Pagination: 4-24 Citation Subset: IM |
Affiliation:
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University of California San Francisco, San Francisco, California, USA. rauenk@peds.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans MAP Kinase Signaling System* Syndrome ras Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD048502/HD/NICHD NIH HHS; HD061140/HD/NICHD NIH HHS; K23 HD048502-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.6.5.2/ras Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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