| Procalcitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 19585221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Procalcitonin (PCT) is known to be a biological diagnostic marker for severe sepsis, or septic shock in critically ill patients. There are still contrasting data about a role of procalcitonin in patients with acute myocardial infarction or cardiogenic shock, and in those with acute coronary syndromes, that is, non-ST-elevation myocardial infarction or unstable angina. We evaluated plasma levels of procalcitonin and C-reactive protein (CRP) in 52 patients admitted to our intensive cardiac care unit (ICCU): 14 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI), 15 patients with uncomplicated ST-elevation myocardial infarction (STEMI), and 24 with non-ST-elevation myocardial infarction or unstable angina (NSTEMI/UA). In all patients, infective processes were excluded. Procalcitonin values were significantly higher in CS patients with respect to the other two subgroups (P < 0.001, P < 0.001) while CRP levels were higher than NSTEMI/UA patients (P < 0.001) but not with respect to STEMI patients (P = 0.063). No correlations were found in cardiogenic shock patients between CRP and PCT values (R = 0.02; P = 0.762, ns). Procalcitonin levels measured on ICCU admission are significantly higher in patients with cardiogenic shock following the acute myocardial infarction, and they are not correlated with those of CRP. The degree of myocardial ischemia (clinically indicated by the whole spectrum of ACS, from unstable angina to cardiogenic shock ST-elevation following myocardial infarction) and the related inflammatory-induced response are better reflected by CRP (which was positive in most acute cardiac care patients of all our subgroups), than by PCT which seems more reflective of a higher degree of inflammatory activation, being positive only in all CS patients. |
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Authors:
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Claudio Picariello; Chiara Lazzeri; Marco Chiostri; Gianfranco Gensini; Serafina Valente |
Publication Detail:
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Type: Journal Article Date: 2009-07-08 |
Journal Detail:
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Title: Internal and emergency medicine Volume: 4 ISSN: 1970-9366 ISO Abbreviation: Intern Emerg Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101263418 Medline TA: Intern Emerg Med Country: Italy |
Other Details:
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Languages: eng Pagination: 403-8 Citation Subset: IM |
Affiliation:
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Intensive Cardiac Care Unit, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50184 Florence, Italy. claudx@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome*
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diagnosis,
physiopathology Aged Aged, 80 and over Angina, Unstable Biological Markers / blood C-Reactive Protein / analysis Calcitonin / blood* Female Humans Inflammation Intensive Care Units Italy Male Middle Aged Myocardial Infarction Protein Precursors / blood* Shock, Cardiogenic* / diagnosis, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Intern Emerg Med. 2009 Oct;4(5):363-5
[PMID:
19639270
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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