| Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates. | |
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MedLine Citation:
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PMID: 17927729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To examine the diagnostic usefulness of procalcitonin (PCT), C-reactive protein and immature to total neutrophil ratio (I : T) in nosocomial sepsis among neonates treated in an intensive care unit. METHODS: A retrospective analysis and comparison of diagnostic utility performed in preterm neonates using receiver operating characteristic curves for the diagnosis of culture-proven sepsis. RESULTS: A total of 78 clinically suspected sepsis episodes in 73 newborns were analysed. The median values of PCT were: 0.56 ng/mL (interquartile range (IQR) 0.33-1.32) in group with aseptic blood culture (n = 15), 2.69 ng/mL (IQR 1.10-5.29) in Gram-positive (n = 47) and 9.36 ng/mL (IQR 3.11-39.35) in Gram-negative sepsis (n = 16). Only PCT values were significantly different (P < 0.01) among all groups. This was also true when correction for differences in blood withdrawal time was implemented. The positive and negative predictive values of PCT in the diagnosis of sepsis equalled 97.5% and 88.9%, respectively, for a cut-off value of 0.99 ng/mL. PCT was significantly better in diagnosis of sepsis than I : T (P = 0.03). No other significant differences in diagnostic efficacy were noted. The diagnostic efficacy was the highest for measurements made two or more hours since the onset of symptoms. CONCLUSIONS: The PCT serum concentration is a valuable tool for early detection of nosocomial sepsis in infants. Highest levels of PCT were observed in Gram-negative infections. |
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Authors:
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Wojciech M Fendler; Andrzej J Piotrowski |
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Publication Detail:
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Type: Journal Article Date: 2007-10-10 |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: 44 ISSN: 1440-1754 ISO Abbreviation: J Paediatr Child Health Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-29 Completed Date: 2008-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: Australia |
Other Details:
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Languages: eng Pagination: 114-8 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, Paediatric University Hospital, Medical University in Lodz, Lodz, Poland. fendler.wojciech@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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metabolism* Calcitonin / blood* Cross Infection / blood, diagnosis*, microbiology Female Gram-Negative Bacterial Infections / blood, diagnosis Gram-Positive Bacterial Infections / blood, diagnosis Humans Infant, Newborn Infant, Premature Intensive Care Units, Neonatal Male Protein Precursors / blood* ROC Curve Retrospective Studies Sepsis / blood, diagnosis*, microbiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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