Document Detail

Procalcitonin in detecting neonatal nosocomial sepsis.
MedLine Citation:
PMID:  22933097     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates.
SETTING: Six neonatal intensive care units (NICUs).
PATIENTS: 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission.
MAIN OUTCOME MEASURES: Positive and negative predictive values at different PCT cut-off levels.
RESULTS: The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients.
CONCLUSIONS: In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS.
Cinzia Auriti; Ersilia Fiscarelli; Maria Paola Ronchetti; Marta Argentieri; Gabriella Marrocco; Anna Quondamcarlo; Giulio Seganti; Francesco Bagnoli; Giuseppe Buonocore; Giovanni Serra; Gianfranco Bacolla; Savino Mastropasqua; Annibale Mari; Carlo Corchia; Giusi Prencipe; Fiammetta Piersigilli; Lucilla Ravà; Vincenzo Di Ciommo
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  97     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-20     Revised Date:  2012-12-14    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F368-70     Citation Subset:  AIM; IM    
Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Piazza S Onofrio, 4-00165 Rome, Italy.
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MeSH Terms
Calcitonin / blood*
Cross Infection / diagnosis*
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Likelihood Functions
Protein Precursors / blood*
ROC Curve
Sensitivity and Specificity
Sepsis / diagnosis*
Reg. No./Substance:
0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin
Erratum In:
Arch Dis Child Fetal Neonatal Ed. 2012 Nov;97(6):F488

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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