Document Detail

Procalcitonin in detecting neonatal nosocomial sepsis.
MedLine Citation:
PMID:  21406453     Owner:  NLM     Status:  Publisher    
Objective To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. Setting Six neonatal intensive care units (NICUs). Patients 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. Main outcome measures Positive and negative predictive values at different PCT cut-off levels. Results The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. Conclusions In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS.
Cinzia Auriti; Ersilia Fiscarelli; Maria Paola Ronchetti; Marta Argentieri; Gabriella Marrocco; Anna Quondamcarlo; Giulio Seganti; Francesco Bagnoli; Giuseppe Buonocore; Giovanni Serra; Gianfranco Bacolla; Savino Mastropasqua; Annibale Mari; Carlo Corchia; Giusi Prencipe; Fiammetta Piersigilli; Lucilla Ravà; Vincenzo Di Ciommo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  -     ISSN:  1468-2052     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy.
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