| Procalcitonin in detecting neonatal nosocomial sepsis. | |
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MedLine Citation:
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PMID: 21406453 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. Setting Six neonatal intensive care units (NICUs). Patients 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. Main outcome measures Positive and negative predictive values at different PCT cut-off levels. Results The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. Conclusions In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS. |
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Authors:
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Cinzia Auriti; Ersilia Fiscarelli; Maria Paola Ronchetti; Marta Argentieri; Gabriella Marrocco; Anna Quondamcarlo; Giulio Seganti; Francesco Bagnoli; Giuseppe Buonocore; Giovanni Serra; Gianfranco Bacolla; Savino Mastropasqua; Annibale Mari; Carlo Corchia; Giusi Prencipe; Fiammetta Piersigilli; Lucilla Ravà; Vincenzo Di Ciommo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: - ISSN: 1468-2052 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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