Document Detail


Procalcitonin for early prediction of survival outcome in postoperative critically ill patients with severe sepsis.
MedLine Citation:
PMID:  16849384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Identification of postoperative patients at high risk of dying early after intensive care unit (ICU) admission through a fast and readily available parameter may help in determining therapeutic interventions or further diagnostic procedures that could have an impact on patients' outcome. The aim of our study was to assess the utility of procalcitonin (PCT) and other readily available parameters, as useful early (days 1-3) predictors of mortality in postoperative patients diagnosed with severe sepsis within 24 h preceding their operation. METHODS: More than a period of 2 yr, subsets of 69 postoperative patients admitted with severe sepsis and 890 non-septic ICU patients were investigated. PCT, C-reactive protein (CRP) and sequential organ failure assessment (SOFA) score were recorded over the duration of ICU stay. RESULTS: PCT area under receiver operating characteristic (ROC) curve was 0.78 on day 3 and was highly predictive of fatal outcome (0.90) at day 6. Area under ROC curve of SOFA score was 0.85 on day 3 and remained in this range until day 6. Area under ROC curves on day 3 of CRP (0.61) was non-predictive and remained non-predictive over the duration of ICU stay. CONCLUSIONS: PCT exhibited no discriminative power early after ICU admission for prediction of mortality in critically ill patients with severe sepsis, compared with a high predictive power of SOFA score on day 3. However, using PCT could still serve as a useful complementary comparator for prediction of survival outcome using the SOFA score.
Authors:
A A Dahaba; B Hagara; A Fall; P H Rehak; W F List; H Metzler
Related Documents :
20495714 - Validation of a prediction rule to maximize curative (r0) resection of early-stage panc...
20064814 - The experts debate: perioperative beta-blockade for noncardiac surgery--proven safe or ...
24680144 - Elimination of laparoscopic lens fogging using directional flow of co2.
21400414 - Focused ultrasound: the future of noninvasive surgery.
17657154 - Use of topical hemostatic agents during liver resection.
11490814 - Inflammatory pseudotumors of the liver: prevalence and clinical impact in surgical pati...
Publication Detail:
Type:  Journal Article     Date:  2006-07-18
Journal Detail:
Title:  British journal of anaesthesia     Volume:  97     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, Graz Medical University, Graz, Austria. ashraf.dahaba@meduni-graz.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
C-Reactive Protein / metabolism
Calcitonin / blood*
Critical Illness / therapy*
Female
Humans
Intensive Care
Length of Stay
Male
Middle Aged
Multiple Organ Failure / blood,  therapy
Postoperative Complications / blood*,  therapy
Prognosis
Protein Precursors / blood*
ROC Curve
Sepsis / blood*,  microbiology
Severity of Illness Index
Survival Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral state index: comparison between pairwise registrations from the left and the right sides of...
Next Document:  Development of torsade de pointes caused by exacerbation of QT prolongation during clipping of cereb...