Document Detail

Procalcitonin for early prediction of survival outcome in postoperative critically ill patients with severe sepsis.
MedLine Citation:
PMID:  16849384     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Identification of postoperative patients at high risk of dying early after intensive care unit (ICU) admission through a fast and readily available parameter may help in determining therapeutic interventions or further diagnostic procedures that could have an impact on patients' outcome. The aim of our study was to assess the utility of procalcitonin (PCT) and other readily available parameters, as useful early (days 1-3) predictors of mortality in postoperative patients diagnosed with severe sepsis within 24 h preceding their operation. METHODS: More than a period of 2 yr, subsets of 69 postoperative patients admitted with severe sepsis and 890 non-septic ICU patients were investigated. PCT, C-reactive protein (CRP) and sequential organ failure assessment (SOFA) score were recorded over the duration of ICU stay. RESULTS: PCT area under receiver operating characteristic (ROC) curve was 0.78 on day 3 and was highly predictive of fatal outcome (0.90) at day 6. Area under ROC curve of SOFA score was 0.85 on day 3 and remained in this range until day 6. Area under ROC curves on day 3 of CRP (0.61) was non-predictive and remained non-predictive over the duration of ICU stay. CONCLUSIONS: PCT exhibited no discriminative power early after ICU admission for prediction of mortality in critically ill patients with severe sepsis, compared with a high predictive power of SOFA score on day 3. However, using PCT could still serve as a useful complementary comparator for prediction of survival outcome using the SOFA score.
A A Dahaba; B Hagara; A Fall; P H Rehak; W F List; H Metzler
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Publication Detail:
Type:  Journal Article     Date:  2006-07-18
Journal Detail:
Title:  British journal of anaesthesia     Volume:  97     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care Medicine, Graz Medical University, Graz, Austria.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism
Calcitonin / blood*
Critical Illness / therapy*
Intensive Care
Length of Stay
Middle Aged
Multiple Organ Failure / blood,  therapy
Postoperative Complications / blood*,  therapy
Protein Precursors / blood*
ROC Curve
Sepsis / blood*,  microbiology
Severity of Illness Index
Survival Analysis
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

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