Document Detail


Procalcitonin, c-reactive protein and neopterin levels in patients with coronary atherosclerosis.
MedLine Citation:
PMID:  16128367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recent studies demonstrate that the serum inflammatory markers increase in patients with atherosclerosis. We aimed to assess whether a difference exists between patients with acute coronary syndrome and patients with stable angina pectoris in respect to serum neopterin, procalcitonin (PCT) and C-reactive protein (CRP) levels. METHODS AND RESULTS: A total of 52 patients (42 male, 10 female) who had atherosclerosis confirmed by angiography and were being followed up for an acute coronary syndrome were recruited and for control group, 45 patients with stable angina pectoris (SA) (35 male and 10 female) who underwent coronary angiography, were examined. Serum concentrations of neopterin, CRP and PCT in the study group (acute coronary syndrome) were compared to control group (stable angina pectoris). The mean neopterin level of the study group was 22.47 +/- 2.93 nmol/l, the mean CRP level was 30.40 +/- 8.05 mg/l and the mean PCT level was 0.40 +/- 0.04 ng/ml. In control group these levels were 12.26 +/- 0.61 nmol/l (p < 0.05), 5.26 +/- 0.64 mg/l (p < 0.001) and 0.19 +/- 0.02 ng/ml (p < 0.001), respectively. CONCLUSION: In the presented study our results showed that these markers can be useful for the assessment of inflammation related to atherosclerosis.
Authors:
Fulya Ilhan; Handan Akbulut; Ilgm Karaca; Ahmet Godekmerdan; Erdogan Ilkay; Vedat Bulut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  60     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2006-02-16     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Affiliation:
Department of Immunology, Firat University, Medical Faculty Elazig, Turkey. fulhan23@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / blood
C-Reactive Protein / analysis*
Calcitonin / blood*
Case-Control Studies
Coronary Artery Disease / blood*
Female
Glycoproteins / analysis*
Humans
Male
Middle Aged
Neopterin / blood*
Protein Precursors / blood*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Protein Precursors; 56645-65-9/procalcitonin; 670-65-5/Neopterin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

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