Document Detail


Procalcitonin as a prognostic marker in patients with acute myocardial infarction.
MedLine Citation:
PMID:  20214413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions. AIMS: To investigate the association between procalcitonin and major adverse cardiac events (MACE), left ventricular (LV) function and remodelling following acute myocardial infarction (AMI). METHODS: Plasma procalcitonin was measured in 977 patients with AMI. Subjects were followed for MACE (median 671 days). A subgroup underwent echocardiography at discharge and follow-up LV function and volume assessment. RESULTS: Procalcitonin was associated with MACE on uni- and multivariable analysis. Kaplan-Meier assessment revealed an adverse outcome in subjects with procalcitonin above the median. Procalcitonin was related to markers of LV dysfunction and remodelling. CONCLUSION: Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.
Authors:
Dominic Kelly; Sohail Q Khan; Onkar Dhillon; Paulene Quinn; Joachim Struck; Iain B Squire; Joan E Davies; Leong L Ng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK. kelly.dominic@talk21.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Calcitonin / blood*
Echocardiography
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood,  diagnosis*,  epidemiology
Protein Precursors / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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