| Procalcitonin as a predictive marker of infections in chemoinduced neutropenia. | |
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MedLine Citation:
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PMID: 19876647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was designed to determine the usefulness of procalcitonin (PCT) as a predictive marker of infections in neutropenic patients following chemotherapeutic treatments. METHODS: Over a 6-month period, 65 patients (34 affected by a solid tumor, 31 by a hematological disorder) were enrolled. Serum PCT concentrations were measured by an automated immunoassay on the leucocytes nadir and on the third day, when patients were checked for any sign of infection. RESULTS: Procalcitonin values were not affected by gender, age, therapeutic approach, use of G-CSF or performance status and did not differ between patients who subsequently developed a localized infection and those who did not. PCT concentrations resulted higher in patients affected by hematological disorders than in those affected by solid tumors (mean value 0.09 vs. 0.05 microg/L; p < 0.0015) and in those who were hospitalized than in the outpatient group (0.10 vs. 0.05 microg/L; p < 0.0013). PCT levels correlated with the type of neoplastic disease (p = 0.016), the highest concentrations being detected in patients affected by acute leukemia. CONCLUSIONS: These findings suggest that PCT is not a useful predictive marker of infection in oncohematologic neutropenic patients, even though higher serum PCT concentrations are associated with hematological tumors as well as in-hospital admission. |
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Authors:
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Luisa Carnino; Silvia Betteto; Maria Loiacono; Annalisa Chiappella; Alice Giacobino; Libero Ciuffreda; Patrizia Lista; Giulio Mengozzi |
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Publication Detail:
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Type: Journal Article Date: 2009-10-30 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 136 ISSN: 1432-1335 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 611-5 Citation Subset: IM |
Affiliation:
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Oncohematological Center, San Giovanni Battista University Hospital, Turin, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Calcitonin / blood* Female Hematologic Neoplasms / drug therapy Humans Infection / blood, diagnosis*, etiology Male Neoplasms / drug therapy Neutropenia / chemically induced*, complications, pathology Protein Precursors / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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