Document Detail


Procalcitonin as a parameter of disease severity and risk of mortality in patients with Plasmodium falciparum malaria.
MedLine Citation:
PMID:  11237849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P<.001 among all subgroups). Six of 7 patients with PCT concentrations >25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination.
Authors:
C B Chiwakata; C Manegold; L Bönicke; I Waase; C Jülch; M Dietrich
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Publication Detail:
Type:  Journal Article     Date:  2001-03-01
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  183     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1161-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood*
Calcitonin / blood*
Disease Progression
Follow-Up Studies
Germany
Glycoproteins / blood*
Humans
Malaria, Falciparum / blood*,  mortality
Protein Precursors / blood*
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin
Comments/Corrections
Comment In:
J Infect Dis. 2001 Oct 15;184(8):1091-2   [PMID:  11574929 ]

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