| Probucol reduces plasma lipid peroxides in man. | |
| | |
MedLine Citation:
|
PMID: 1445494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although primarily used as a lipid lowering drug, probucol also possesses anti-oxidant activity and has been shown in animal models to inhibit or delay the progression of atherosclerosis. It has been suggested that this anti-atherosclerotic effect may occur through inhibition of free radical oxidation of low density lipoprotein. The aim of this study was to investigate the effects of probucol on free radical activity in hyperlipidaemic patients. Plasma lipid peroxides were measured before probucol treatment, at 4 and 12 weeks treatment and then 4 weeks after stopping probucol. Lipid peroxide concentrations were significantly reduced during and 4 weeks after stopping treatment with probucol, when compared with baseline values. There were no changes in plasma vitamin E concentrations. The results of this study indicate that probucol reduces lipid peroxidation in patients, an effect which may occur through a free radical scavenging action. |
| | |
Authors:
|
J R Paterson; A G Rumley; K G Oldroyd; G W Tait; W S Smellie; C J Packard; J Shepherd; A R Lorimer |
Related Documents
:
|
15752284 - Evaluation of nitrosative and oxidative stress in behçet disease. 10781654 - Alpha-tocopherol supplementation decreases the oxidative susceptibility of ldl in renal... 16753834 - Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a fiv... 15877874 - Elements of mediterranean diet improve oxidative status in blood of kidney graft recipi... 7036514 - Recognizing potential toxicity of phenol. 3177084 - Hypothesis: posture is one of the determinants of the circadian rhythm of urine flow an... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Atherosclerosis Volume: 97 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1992 Nov |
Date Detail:
|
Created Date: 1992-12-14 Completed Date: 1992-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 63-6 Citation Subset: IM |
Affiliation:
|
Institute of Biochemistry, Royal Infirmary, Glasgow, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cholesterol / blood Humans Hyperlipidemias / blood, drug therapy Lipid Peroxides / blood* Male Middle Aged Probucol / therapeutic use* Vitamin E / blood |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Peroxides; 1406-18-4/Vitamin E; 23288-49-5/Probucol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute physical exercise alters apolipoprotein E and C-III concentrations of apo E-rich very low dens...
Next Document: Hageman factor and risk of myocardial infarction in middle-aged men.