Document Detail

Probucol reduces plasma lipid peroxides in man.
MedLine Citation:
PMID:  1445494     Owner:  NLM     Status:  MEDLINE    
Although primarily used as a lipid lowering drug, probucol also possesses anti-oxidant activity and has been shown in animal models to inhibit or delay the progression of atherosclerosis. It has been suggested that this anti-atherosclerotic effect may occur through inhibition of free radical oxidation of low density lipoprotein. The aim of this study was to investigate the effects of probucol on free radical activity in hyperlipidaemic patients. Plasma lipid peroxides were measured before probucol treatment, at 4 and 12 weeks treatment and then 4 weeks after stopping probucol. Lipid peroxide concentrations were significantly reduced during and 4 weeks after stopping treatment with probucol, when compared with baseline values. There were no changes in plasma vitamin E concentrations. The results of this study indicate that probucol reduces lipid peroxidation in patients, an effect which may occur through a free radical scavenging action.
J R Paterson; A G Rumley; K G Oldroyd; G W Tait; W S Smellie; C J Packard; J Shepherd; A R Lorimer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  97     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-14     Completed Date:  1992-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Institute of Biochemistry, Royal Infirmary, Glasgow, UK.
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MeSH Terms
Cholesterol / blood
Hyperlipidemias / blood,  drug therapy
Lipid Peroxides / blood*
Middle Aged
Probucol / therapeutic use*
Vitamin E / blood
Reg. No./Substance:
0/Lipid Peroxides; 1406-18-4/Vitamin E; 23288-49-5/Probucol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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