Document Detail

Probucol reduces hepatic cholesterol secretion in hyperlipidemic Yoshida rats.
MedLine Citation:
PMID:  8808499     Owner:  NLM     Status:  MEDLINE    
In this study, perfused livers from Yoshida rats, either on a normal diet or on a diet with 0.3% probucol, were examined. The analysis of liver lipid content and of bile and lipoprotein secretion changes showed that probucol had a relevant effect on liver lipid biosynthesis. In particular, it reduced the production of triacylglycerols and, to a much greater extent that of cholesterol. In addition, probucol reduced plasma cholesterol concentration by decreasing esterified cholesterol in HDL1 and HDL2 fractions. Furthermore, HDL1 composition of both hepatic neosynthetized and circulating particles was strongly modified by probucol. Finally, probucol did not appear to induce significant differences in lipid bile secretion while phospholipid secretion from perfused livers was increased. These facts suggest that the hypolipidemic action of probucol is not mediated by an increase in bile steroid secretion, but rather by a direct reduction in hepatic lipoprotein cholesterol secretion. This secretion induces a modified plasma profile of HDL particles such that these variations are advantageous in terms of reverse cholesterol transport.
E Bravo; G Ortu; R Rivabene; M T Santini; A Cantafora
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  119     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-25     Completed Date:  1996-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanitá, Roma, Italy.
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MeSH Terms
Anticholesteremic Agents / pharmacology*
Bile / secretion
Body Weight / drug effects
Cholesterol / blood,  secretion*
Cholesterol Esters / blood
Cholesterol, HDL / blood
Hyperlipidemias / blood,  drug therapy*,  genetics,  physiopathology
Lipids / biosynthesis
Lipoproteins / secretion
Liver / drug effects*,  secretion
Probucol / pharmacology*
Rats, Mutant Strains
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Lipids; 0/Lipoproteins; 23288-49-5/Probucol; 57-88-5/Cholesterol

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