| Problems with 'focal segmental glomerulosclerosis'. | |
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MedLine Citation:
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PMID: 21125407 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The term 'focal segmental glomerulosclerosis (FSGS)' has been applied to many different conditions. All classifications of 'FSGS', including those describing 'variants', perpetuate the misconceptions that the entities included have something in common and that the term 'FSGS' has some value. With a rigorous approach to renal biopsies showing segmental lesions, especially with knowledge of clinical circumstances and with detailed analysis of features such as the appearance of lesions and their position within glomeruli, a pathologist can provide information that is clinically more useful than merely the bald diagnosis 'FSGS'. More precise terms should be used. 'Overload changes' can be used to describe the changes seen in reduced renal mass. 'Tip changes' can be seen in many conditions and are not a disease in themselves. 'The glomerular tip lesion as originally defined' means the occurrence of tip changes in otherwise normal glomeruli, in the nephrotic syndrome. 'Early classical segmental sclerosing glomerulopathy' is the combination of tip changes and otherwise abnormal glomeruli, in the nephrotic syndrome. 'Late classical segmental sclerosing glomerulopathy' means segmental lesions at various sites within glomeruli, in the nephrotic syndrome. 'Collapsing glomerulopathy' is distinctive, and its inclusion in classifications emphasises the lack of specificity of 'FSGS'. |
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Authors:
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Alexander J Howie |
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Publication Detail:
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Type: Journal Article Date: 2010-12-02 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 26 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1197-205 Citation Subset: IM |
Affiliation:
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Department of Pathology, University College London, London, WC1E 6JJ, UK, a.j.howie@medsch.ucl.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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