Document Detail

Problems with determining the hypoxic response in humans using stepwise changes in end-tidal PO2.
MedLine Citation:
PMID:  7899726     Owner:  NLM     Status:  MEDLINE    
This study examined whether the form of the acute ventilatory response to different levels of end-tidal PO2 (PETO2) could be determined from a progressive series of steps in PETO2 at constant end-tidal PCO2. Seven levels of PETO2 were employed each lasting 2 min. The steps were performed in both ascending and descending order to test whether the ventilatory responses were affected by the order of the hypoxic exposures. These exposures were carried out both with and without a prior 20 min period of isocapnic hypoxia (PETO2 = 50 mmHg). Each protocol was undertaken 6 times in each of 6 subjects. With prior exposure to hypoxia, the order in which the steps were performed affected the ventilatory response (P < 0.005, ANOVA). Without prior exposure to hypoxia, this finding did not quite reach significance (P < 0.056), unless one particular abnormal subject was excluded (P < 0.001). It is concluded that the order of the hypoxic exposures in this particular test affects the form of the hypoxic response.
L S Howard; P A Robbins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  98     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
University Laboratory of Physiology, Oxford, UK.
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MeSH Terms
Anoxia / physiopathology*
Carbon Dioxide / analysis
Oxygen / analysis*
Respiration / physiology*
Respiratory Function Tests
Grant Support
//Wellcome Trust
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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