Document Detail

Problems in pharmacological evaluation of patients with paroxysmal atrial fibrillation: clinical analysis of more than 100 consecutive patients.
MedLine Citation:
PMID:  9932629     Owner:  NLM     Status:  MEDLINE    
To address the problems of pharmacological evaluation in paroxysmal atrial fibrillation (PAf), we interviewed 108 consecutive patients with documented PAf regarding symptoms, frequency and trigger factors of PAf and analyzed the 24-hour ambulatory electrocardiographic monitoring (Holter monitoring) records in relation to symptoms. Twenty-nine patients were totally asymptomatic, while 79 patients were symptomatic of which 49 patients had obvious trigger factors. PAf was documented by Holter monitoring in 22 of 79 symptomatic patients. On analysis of PAf-documented 25 Holter monitoring records, the patients checked event marks as PAf in only 20 of 155 PAf episodes. Six episodes of 26 event marks that patients thought to be PAf proved to be premature atrial or ventricular contractions. Nine patients in whom PAf persisted for more than 24 hours became asymptomatic. Patients suitable for pharmacological evaluation constituted about one-fifth of the PAf patients in our consecutive study. Even with the selection of these patients, pharmacological evaluation based on symptoms is difficult because disappearance of PAf may be associated with persistent atrial fibrillation.
K Iga; C Izumi; A Nakano; Y Sakanoue; T Miyamoto; S Kitaguchi; Y Himura; H Gen; T Konishi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  37     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-31     Completed Date:  1999-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1005-8     Citation Subset:  IM    
Department of Cardiology, Tenri Hospital.
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MeSH Terms
Aged, 80 and over
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / drug therapy*,  physiopathology
Electrocardiography, Ambulatory* / drug effects
Follow-Up Studies
Heart Rate / drug effects
Middle Aged
Reproducibility of Results
Tachycardia, Paroxysmal / drug therapy*,  physiopathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents
Comment In:
Intern Med. 1998 Dec;37(12):997-8   [PMID:  9932625 ]

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