| Problems in pharmacological evaluation of patients with paroxysmal atrial fibrillation: clinical analysis of more than 100 consecutive patients. | |
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MedLine Citation:
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PMID: 9932629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To address the problems of pharmacological evaluation in paroxysmal atrial fibrillation (PAf), we interviewed 108 consecutive patients with documented PAf regarding symptoms, frequency and trigger factors of PAf and analyzed the 24-hour ambulatory electrocardiographic monitoring (Holter monitoring) records in relation to symptoms. Twenty-nine patients were totally asymptomatic, while 79 patients were symptomatic of which 49 patients had obvious trigger factors. PAf was documented by Holter monitoring in 22 of 79 symptomatic patients. On analysis of PAf-documented 25 Holter monitoring records, the patients checked event marks as PAf in only 20 of 155 PAf episodes. Six episodes of 26 event marks that patients thought to be PAf proved to be premature atrial or ventricular contractions. Nine patients in whom PAf persisted for more than 24 hours became asymptomatic. Patients suitable for pharmacological evaluation constituted about one-fifth of the PAf patients in our consecutive study. Even with the selection of these patients, pharmacological evaluation based on symptoms is difficult because disappearance of PAf may be associated with persistent atrial fibrillation. |
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Authors:
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K Iga; C Izumi; A Nakano; Y Sakanoue; T Miyamoto; S Kitaguchi; Y Himura; H Gen; T Konishi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 37 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-31 Completed Date: 1999-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1005-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Tenri Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Arrhythmia Agents / therapeutic use* Atrial Fibrillation / drug therapy*, physiopathology Electrocardiography, Ambulatory* / drug effects Female Follow-Up Studies Heart Rate / drug effects Humans Male Middle Aged Questionnaires Reproducibility of Results Tachycardia, Paroxysmal / drug therapy*, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents |
| Comments/Corrections | |
Comment In:
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Intern Med. 1998 Dec;37(12):997-8
[PMID:
9932625
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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