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Probiotics to obese adolescents; RCT examining the effects on inflammation and metabolic syndrome.
MedLine Citation:
PMID:  22695039     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: The connection between gut microbiota, energy homeostasis and inflammation, and its role in the pathogenesis of obesity-related disorders are increasingly recognized. We aimed to investigate the effect of the probiotic strain Lactobacillus salivarius Ls-33 on a series of biomarkers related to inflammation and the metabolic syndrome (MS) in obese adolescents. METHODS:: The study was a double blinded placebo controlled trial including 50 obese adolescents randomized to Ls-33 (10 CFU) or placebo daily for 12 weeks. RESULTS:: The average BMI-for-age Z-score was 2.6 ± 0.5. There were no differences in biomarkers of inflammation and parameters related to the metabolic syndrome at baseline between the probiotic and placebo groups. Furthermore, there were no differences in changes from baseline to 12 weeks intervention with regard to any anthropometric measures, blood pressure (systolic and diastolic), fasting glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), C-peptide, cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), triglyceride (TG), free fatty acids (FFA), C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α) or faecal calprotectin (FC), despite the increased values of biomarkers of inflammation and of several parameters related to the metabolic syndrome at baseline when compared to normal weight adolescents. The levels of L. salivarius in fecal samples from the probiotic group in this study were comparable with the levels reported for the other probiotic lactobacilli and bifidobacteria using qPCR. CONCLUSION:: It was not possible to detect any beneficial effect of the probiotic intervention with Ls-33 on inflammatory markers or parameters related to the MS in obese adolescents being in a state of low grade systemic inflammation.
Rikke Juul Gøbel; Nadja Larsen; Mogens Jakobsen; Christian Mølgaard; Kim Fleischer Michaelsen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-12
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Department of Human Nutrition, Faculty of Sciences, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg, Denmark †Department of Food Science, Faculty of Sciences, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg, Denmark.
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