| Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. | |
| | |
MedLine Citation:
|
PMID: 22955355 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: : It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology. OBJECTIVE: : The aim of this randomized double-blinded active treatment versus placebo study was to evaluate clinical efficacy of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) for the treatment of adult AD patients. METHODS: : Forty-eight patients were enrolled in the study (randomization ratio 2:1) and treated with a combination (LS01 and BR03) or placebo (maltodextrin) for 12 weeks. Clinical efficacy was assessed from baseline by changes in the SCORAD index and DLQ index improvement. Analysis on the gut permeability barrier, immunologic parameters, and changes in fecal microbiota and recovery of probiotics were performed at baseline, at the end of therapy, and 2 months later. RESULTS: : Patients receiving probiotics showed a significant improvement in clinical parameters (SCORAD, P<0.0001 and DLQ index, P=0.021) from baseline. The probiotics reduced microbial translocation (P=0.050), immune activation (P<0.001), improved T-helper cell (Th)17/regulatory T cell (Treg) (P=0.029) and Th1/Th2 (P=0.028) ratios. None of these changes were observed in the placebo group. CONCLUSIONS: : Our results suggest that this specific mixture of probiotics (LS01 and BR03 strains) may induce beneficial effects for clinical and immunologic alterations in adult AD. This combination could be considered as adjuvant therapy for the treatment of AD in adult patients. |
| | |
Authors:
|
Enrico Iemoli; Daria Trabattoni; Serena Parisotto; Linda Borgonovo; Marco Toscano; Giuliano Rizzardini; Mario Clerici; Elena Ricci; Alessandra Fusi; Elena De Vecchi; Stefania Piconi; Lorenzo Drago |
Related Documents
:
|
17432635 - Problem-solving early intervention: a pilot study of stroke caregivers. 12700625 - A one-quarter reduction in the salt content of bread can be made without detection. 11904025 - Prognostic significance of hypernatremia and hyponatremia among patients with aneurysma... 8773035 - A double blind placebo controlled trial of ginkgo biloba extract in acute cerebral isch... 20546375 - Poor blood pressure and urinary albumin excretion responses to home blood pressure-base... 8389895 - Nicotine treatment at the drug dependency program of the minneapolis va medical center.... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 46 Suppl ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: S33-40 Citation Subset: IM |
Affiliation:
|
*Allergy and Clinical Immunology Unit, "L. Sacco" Hospital †Department of Immunology ‡Laboratory of Clinical Microbiology, Department of Clinical Sciences L. Sacco, University of Milan §Don Gnocchi Foundation ∥Laboratory of Clinical Chemistry and Microbiology, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unfolded protein responses in the intestinal epithelium: sensors for the microbial and metabolic env...
Next Document: Selenium and Zinc Internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis...