Document Detail


Probiotics in diverticular disease of the colon: an open label study.
MedLine Citation:
PMID:  20361072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the effectiveness and safety of a symbiotic mixture in preventing recurrence of constipation-related abdominal pain in patients with uncomplicated diverticular disease of the colon.
METHODS: Forty-six consecutive patients (10 men, 36 women, mean age 62.5 years, range 49 to 77 years), previously affected by symptomatic uncomplicated diverticular disease of the colon, were enrolled in a 6-month follow-up study in a prospective, randomized, open-label study. The following symptoms were assessed at entry and through follow-up by using a quantitative scale: constipation, diarrhoea and abdominal pain. After recruitment, the patients were assigned to the following treatment: SCM-III symbiotic mixture, 10 ml three times a day. The colonization of ingested Lactobacillus acidophilus 145 and Bifidobacterium spp. 420 was assessed by species-specific PCR. Forty-five patients completed the study (97%).
RESULTS: Thirty-one patients (68%) were still symptom free after the 6th month of treatment. Treatment with SCM-III was regarded as "effective" or "very effective" in more than 78% of the patients altogether (p<0.01 vs baseline values). The microbiological study showed that, as compared to baseline values, SCM-III enabled a significant increase of the lactobacilli and bifidobacteria counting and a trend decrease of clostridia. Genomic analysis confirmed the survivability of the ingested strain as long as treatment was given.
CONCLUSIONS: The present symbiotic mixture seems to be effective in preventing recurrence of symptomatic uncomplicated diverticular disease of the colon, especially in those patients with constipation-predominant features.
Authors:
Pepu Lamiki; Junji Tsuchiya; Surajit Pathak; Ruichi Okura; Umberto Solimene; Shalini Jain; Shichiro Kawakita; Francesco Marotta
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of gastrointestinal and liver diseases : JGLD     Volume:  19     ISSN:  1841-8724     ISO Abbreviation:  J Gastrointestin Liver Dis     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-09-07     Revised Date:  2010-11-22    
Medline Journal Info:
Nlm Unique ID:  101272825     Medline TA:  J Gastrointestin Liver Dis     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Affiliation:
TMC Hospital, Shizuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / etiology,  microbiology,  therapy*
Aged
Bifidobacterium / genetics,  growth & development*
Colon / microbiology*
Constipation / etiology,  microbiology,  therapy*
DNA, Bacterial / isolation & purification
Diverticulum, Colon / complications,  microbiology,  therapy*
Feces / microbiology
Female
Humans
Lactobacillus acidophilus / genetics,  growth & development*
Male
Middle Aged
Polymerase Chain Reaction
Probiotics / therapeutic use*
Prospective Studies
Recurrence / prevention & control
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/DNA, Bacterial
Comments/Corrections
Comment In:
J Gastrointestin Liver Dis. 2010 Jun;19(2):127-9   [PMID:  20593043 ]

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