| Probiotics and allergy. | |
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MedLine Citation:
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PMID: 16313688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergy is caused by an immune reaction that is out of all proportion to the antigenic stimuli. Classical allergy is a type I hypersensitivity reaction mediated by the interaction of mast cells (and eosinophils) coated with allergen-specific IgE and a cross-linking allergen. The physiological outcome is inflammation commonly displayed by urticaria, rhinitis, vomiting and diarrhoea, depending on the route of allergen entry. In extreme reactions anaphylactic shock can result that may lead to death. Chronic allergic responses most commonly present themselves as asthma and eczema. All these symptoms are the consequence of an imbalanced immune system making an unsuitable response to an environmental or food antigen. On bacterial colonisation of the colon after birth the appropriate microbiological stimuli is essential to redress the balance of the skewed T-helper 2 immune response present in the newborn. This normal interaction between baby and microbes is thought to be compromised in the Western world, with a reduction in bifidobacteria and an increase in clostridial species, particularly in bottle-fed infants. The use of probiotic therapy to prevent allergic disease has been demonstrated in two studies using a probiotic Lactobacillus rhamnosus GG in neonates. A long-term reduction in allergy has been shown in the test group, with lactobacillus reducing the incidence of atopic eczema. Management of allergy through probiotics has also been demonstrated in infants, using lactobacilli to control atopic eczema and cow's milk allergy. Unfortunately, these positive results have not been repeated in studies with older children and young adults. |
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Authors:
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Elizabeth Furrie |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Proceedings of the Nutrition Society Volume: 64 ISSN: 0029-6651 ISO Abbreviation: Proc Nutr Soc Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-29 Completed Date: 2006-03-16 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 7505881 Medline TA: Proc Nutr Soc Country: England |
Other Details:
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Languages: eng Pagination: 465-9 Citation Subset: IM |
Affiliation:
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Department of Immunology, Ninewells Hospital and Medical School, Dundee, UK. elizabeth.furrie@tuht.scot.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / diet therapy, prevention & control Colon / microbiology Dermatitis, Atopic / diet therapy, prevention & control Food Hypersensitivity / diet therapy, prevention & control* Humans Infant Inflammation / diet therapy, prevention & control Lactobacillus / growth & development, immunology* Primary Prevention* Probiotics / administration & dosage, therapeutic use* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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