Document Detail

Probiotics for prevention of necrotising enterocolitis: an updated meta-analysis.
MedLine Citation:
PMID:  20645240     Owner:  NLM     Status:  MEDLINE    
Several randomized controlled trials (RCTs) have investigated the prophylactic use of probiotics in preterm infants aimed at reducing the rate of necrotising enterocolitis (NEC). There are 4 meta-analyses on this subject. 2 more RCTs have been published since these meta-analyses were completed. Each meta-analysis, as well as the 2 recent RCTs, document reduced rates of NEC and mortality with the use of prophylactic probiotics. We calculated meta-analyses based on 3 approaches: A - RCTs common to all meta-analyses, B - RCTs ever accounted for in a meta-analysis but not common to all, and C - the 2 recent RCTs. The 3 subgroups yield similar results, with an overall reduction in the relative risk (RR) of NEC (Bell > or =2) to 0.35 (95% CI 0.23-0.55) and of mortality to 0.41 (0.28-0.60). NEC rates and mortalities in the dominant RCTs are in the range reported from North American and European networks. Best results appear to be achieved with probiotics based on 2 or more probiotic species and/or with a combination of Bifidusbacterium spp. and Lactobacillus acidophilus. No unwanted side effects have been reported among 1 117 infants randomized to receive probiotics. We conclude that probiotics are safe and beneficial in preterm infants at risk for NEC.
F Guthmann; C Kluthe; C Bührer
Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2010-07-19
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  222     ISSN:  1439-3824     ISO Abbreviation:  Klin Padiatr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  284-90     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart, New York.
Klinik für Neonatologie, Charité Universitätsmedizin Berlin, Germany.
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MeSH Terms
Cross-Sectional Studies
Enterocolitis, Necrotizing / mortality,  prevention & control*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Very Low Birth Weight*
North America
Probiotics / therapeutic use*
Randomized Controlled Trials as Topic
Survival Rate
Comment In:
Klin Padiatr. 2010 Sep;222(5):282-3   [PMID:  20806165 ]

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