Document Detail


Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study.
MedLine Citation:
PMID:  22452604     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Probiotics survive in gastric environment competing with H. pylori. We studied probiotic "multistrain" administration in dyspeptics with H. pylori (placebo-controlled study). Forty patients with H. pylori (urea breath test - UBT - and IgG) were treated for 10 days with a mixture of 8 species of probiotics. Control group of represented by 40 positive subjects received placebo. A second UBT and H. pylori stool antigen (HpSA) detection were performed after 1 month. Still positive patients who remained infected were treated with triple therapy undergoing another UBT after 30 days. A second line therapy was administered in remaining positive patients. Statistics: Fisher's exact probability and Student's t tests. Thirteen out 40 patients using probiotics became negative, while controls remained positive, irrespectively of independently by the initial UBT delta value. Triple therapy did not show No different difference in the eradication rates between the two groups was found (68%-71%). After second line therapy two patients remained positive. An adequate supplementation with probiotics might eradicate H. pylori.
Authors:
Rosa Rosania; Maria Filomena Minenna; Floriana Giorgio; Antonio Facciorusso; Vincenzo De Francesco; Cesare Hassan; Carmine Panella; Enzo Ierardi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-28
Journal Detail:
Title:  Inflammation & allergy drug targets     Volume:  -     ISSN:  2212-4055     ISO Abbreviation:  Inflamm Allergy Drug Targets     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266886     Medline TA:  Inflamm Allergy Drug Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Gastroenterology Section, Department of Medical Sciences, University of Foggia, Viale Pinto, 1, 71100 Foggia, Italy. enzo.ierardi@fastwenet.it.
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