Document Detail


Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task.
MedLine Citation:
PMID:  17079703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Up to 90% of patients with chronic fatigue syndrome (CFS) report substantial cognitive difficulties. However, objective evidence supporting these claims is inconsistent. The present functional magnetic resonance imaging study examined the neural correlates of working memory in patients with CFS compared with controls. METHODS: Seventeen patients with CFS and 12 healthy control subjects were scanned while performing a parametric version of the n-back task (0-, 1-, 2-, and 3-back). RESULTS: Both groups performed comparably well and activated the verbal working memory network during all task levels. However, during the 1-back condition, patients with CFS showed greater activation than control subjects in medial prefrontal regions, including the anterior cingulate gyrus. Conversely, on the more challenging conditions, patients with CFS demonstrated reduced activation in dorsolateral prefrontal and parietal cortices. Furthermore, on the 2- and 3-back conditions, patients but not control subjects significantly activated a large cluster in the right inferior/medial temporal cortex. Trend analyses of task load demonstrated statistically significant differences in brain activation between the two groups as the demands of the task increased. CONCLUSIONS: These results suggest that patients with CFS show both quantitative and qualitative differences in activation of the working memory network compared with healthy control subjects. It remains to be determined whether these findings stay stable after successful treatment.
Authors:
Xavier Caseras; David Mataix-Cols; Vincent Giampietro; Katharine A Rimes; Michael Brammer; Fernando Zelaya; Trudie Chalder; Emma L Godfrey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-01
Journal Detail:
Title:  Psychosomatic medicine     Volume:  68     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  947-55     Citation Subset:  IM    
Affiliation:
Unitat de Psicologia Mèdica, Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain. x.caseras@iop.kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Fatigue Syndrome, Chronic / complications*,  metabolism*,  psychology
Female
Gyrus Cinguli / metabolism
Humans
Magnetic Resonance Imaging
Male
Memory / physiology*
Middle Aged
Prefrontal Cortex / metabolism
Task Performance and Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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