Document Detail


Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy.
MedLine Citation:
PMID:  22528188     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Single-cell force spectroscopy is an emerging technique in the field of biomedicine because it has proved to be a unique tool to obtain mechanical and functional information on living cells, with force resolution up to single molecular bonds. This technique was applied to the study of the cytoskeleton organisation of neuroblastoma cells, a life-threatening cancer typically developing during childhood, and the results were interpreted on the basis of reference experiments on human embryonic kidney cell line. An intimate connection emerges among cellular state, cytoskeleton organisation and experimental outcome that can be potentially exploited towards a new method for cancer stadiation of neuroblastoma cells. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Andrea Mescola; Serena Vella; Marco Scotto; Paola Gavazzo; Claudio Canale; Alberto Diaspro; Aldo Pagano; Massimo Vassalli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular recognition : JMR     Volume:  25     ISSN:  1099-1352     ISO Abbreviation:  J. Mol. Recognit.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004580     Medline TA:  J Mol Recognit     Country:  England    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Nanophysics Unit, Italian Institute of Technology, Morego, Genova, Italy.
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